Pharmacokinetics of Florfenicol in Serum and Synovial Fluid Samples After Regional Intravneous Perfusion in the Distal Limb of Cattle

Abstract

This study included 6 healthy adult cows. Intravenous catheters were placed in the dorsal common digital vein (DCDV) and plantar vein of the lateral digit (DIG), and an intrasynovial catheter was placed in the metatarsophalangeal (SYN) joint of the left rear limb. Jugular vein samples (JUG) were collected via venipuncture. A pneumatic tourniquet was placed on the mid-metatarsus. Florfenicol was administered at 2.2 mg/kg into the DCDV. DIG, SYN and JUG samples were collected at 15, 30, and 45 minutes. The tourniquet was removed. Sample collection continued at 1, 1.5, 2, 4, 8, 12, 18, and 24 hours post infusion. Florfenicol analysis was performed by high performance liquid chromatography. Findings and Conclusions: The pharmacokinetic parameters of florfenicol following regional intravenous perfusion (RIVP) are shown (table). RIVP of florfenicol produced high concentrations in DIG and SYN samples while the concentration in JUG samples remained relatively low.