dc.contributor.advisor | Streeter, Robert N. | |
dc.contributor.author | Gilliam, John N. | |
dc.date.accessioned | 2014-04-16T03:15:55Z | |
dc.date.available | 2014-04-16T03:15:55Z | |
dc.date.issued | 2007-12-01 | |
dc.identifier.uri | https://hdl.handle.net/11244/9815 | |
dc.description.abstract | This study included 6 healthy adult cows. Intravenous catheters were placed in the dorsal common digital vein (DCDV) and plantar vein of the lateral digit (DIG), and an intrasynovial catheter was placed in the metatarsophalangeal (SYN) joint of the left rear limb. Jugular vein samples (JUG) were collected via venipuncture. A pneumatic tourniquet was placed on the mid-metatarsus. Florfenicol was administered at 2.2 mg/kg into the DCDV. DIG, SYN and JUG samples were collected at 15, 30, and 45 minutes. The tourniquet was removed. Sample collection continued at 1, 1.5, 2, 4, 8, 12, 18, and 24 hours post infusion. Florfenicol analysis was performed by high performance liquid chromatography. Findings and Conclusions: The pharmacokinetic parameters of florfenicol following regional intravenous perfusion (RIVP) are shown (table). RIVP of florfenicol produced high concentrations in DIG and SYN samples while the concentration in JUG samples remained relatively low. | |
dc.format | application/pdf | |
dc.language | en_US | |
dc.publisher | Oklahoma State University | |
dc.rights | Copyright is held by the author who has granted the Oklahoma State University Library the non-exclusive right to share this material in its institutional repository. Contact Digital Library Services at lib-dls@okstate.edu or 405-744-9161 for the permission policy on the use, reproduction or distribution of this material. | |
dc.title | Pharmacokinetics of Florfenicol in Serum and Synovial Fluid Samples After Regional Intravneous Perfusion in the Distal Limb of Cattle | |
dc.type | text | |
dc.contributor.committeeMember | Lehenbauer, Terry W. | |
dc.contributor.committeeMember | Maxwell, Lara K. | |
osu.filename | Gilliam_okstate_0664M_2547.pdf | |
osu.college | Center for Veterinary Health Sciences | |
osu.accesstype | Open Access | |
dc.description.department | Veterinary Pathobiology | |
dc.type.genre | Thesis | |