Mango Modulates Body Fat And Plasma Glucose And Lipids In Mice Fed High Fat Diet

Abstract

Mango is a tropical fruit that contains bioactive compounds that may reduce cardiovascular disease (CVD) risk factors. To our knowledge, limited studies have been conducted to investigate the effect of mango flesh on body composition and glucose and lipid parameters. Therefore, this study compared the effect of mango with known agonist of peroxisome proliferator activated-receptor (PPAR), fenofibrate (PPAR-?-; agonist) and rosiglitazone (PPAR-?; agonist), in modulating body fat, and plasma glucose and lipid parameters in mice fed high fat diet. Male C57BL6 mice were randomly assigned into one of six treatment groups (n=8/group) for two months: high fat diet (HF), HF + fenofibrate (500 mg/kg diet), HF + rosiglitazone (50 mg/kg), HF + 1% mango, and HF + 10% mango. High fat diet significantly increased adipose tissue weight and 1% mango significantly reduced the weights of adipose tissue similar to normal diet, 10% mango, and fenofibrate and rosiglitazone groups. Mice receiving 1% mango groups had the lowest area under the curve after a glucose tolerance test. The two doses of mango significantly reduced plasma non-esterified fatty acids to the level of normal diet group. Overall, supplementation with 1% mango for 8 weeks was the most effective in modulating glucose and lipid levels due to high fat diet. Our findings suggest that incorporation of mango in the diet reduces CVD risk factors in this animal model and warrants further investigation in humans.