Molecular Cloning and Antibacterial Activity of a Lebocin-like Protein from Manduca Sexta
Abstract
Antimicrobial peptides (AMPs) are a critical component of the natural defense system in various organisms. Over 200 AMPs have been identified in arthropods. Most of them are less than 10 kDa, hydrophobic, membrane active, and have net positive charges. At least five different types of AMPs are identified in tobacco hornworm, M. sexta which include attacins, cecropins, moricin, gloverin and lebocin. Here we report screening and isolation of Manduca lebocin cDNA and Genomic clones and also the antibacterial activity of Manduca lebocin derived peptides.
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- OSU Theses [15752]