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Now showing items 11-16 of 16
Crumple: A Method for Complete Enumeration of All Possible Pseudoknot-Free RNA Secondary Structures
(PLos One, 2012-12-27)
The diverse landscape of RNA conformational space includes many canyons and crevices that are distant from the lowest minimum free energy valley and remain unexplored by traditional RNA structure prediction methods. A ...
Similar Gene Estimates from Circular and Linear Standards in Quantitative PCR Analyses Using the Prokaryotic 16S rRNA Gene as a Model
(PLos One, 2012-12-19)
Quantitative PCR (qPCR) is one of the most widely used tools for quantifying absolute numbers of microbial gene copies in test samples. A recent publication showed that circular plasmid DNA standards grossly overestimated ...
Climate and Weather Impact Timing of Emergence of Bats
(PLos One, 2012-08-02)
Interest in forecasting impacts of climate change have heightened attention in recent decades to how animals respond to variation in climate and weather patterns. One difficulty in determining animal response to climate ...
Insights from Characterizing Extinct Human Gut Microbiomes
(PLos One, 2012-12-12)
In an effort to better understand the ancestral state of the human distal gut microbiome, we examine feces retrieved from archaeological contexts (coprolites). To accomplish this, we pyrosequenced the 16S rDNA V3 region ...
Immunodominance of Antigenic Site B over Site A of Hemagglutinin of Recent H3N2 Influenza Viruses
(PLos One, 2012-07-25)
H3N2 influenza viruses have now circulated in the human population for 43 years since the pandemic of 1968, accumulating sequence changes in the hemagglutinin (HA) and neuraminidase (NA) that are believed to be predominantly ...
Structure and Dynamics of Amyloid-β Segmental Polymorphisms
(PLos One, 2012-07-24)
It is believed that amyloid-beta (Aβ) aggregates play a role in the pathogenesis of Alzheimer’s disease. Aβ molecules form β-sheet structures with multiple interaction sites. This polymorphism gives rise to differences in ...