Browsing OU - Faculty and Staff Publications by Author "Tamara T. Hughes"

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    • FXN Promoter Silencing in the Humanized Mouse Model of Friedreich Ataxia 

      Yogesh K. Chutake; Whitney N. Costello; Christina C. Lam; Aniruddha C. Parikh; Tamara T. Hughes; Michael G. Michalopulos; Mark A. Pook; Sanjay I. Bidichandani (PLos One, 2015-09-22)
      Background Friedreich ataxia is caused by an expanded GAA triplet-repeat sequence in intron 1 of the FXN gene that results in epigenetic silencing of the FXN promoter. This silencing mechanism is seen in patient-derived ...