Broadly Protective Shigella Vaccine Based on Type III Secretion Apparatus Proteins
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Date
2016-11-15Author
Picking, Wendy L.
Picking, William D.
Board of Regents/Oklahoma State University and the A & M Colleges
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Broad-based, cross-protective, O-serotype independent vaccines against Shigella and related pathogenic organisms are provided. The vaccines comprise one or more of the type III secretion (TTS) apparatus needle proteins IpaD and IpaB, and/or the IpaB cognate chaperone protein IpgC. Chimeric proteins of IpaD and IpaB, and/or IpgC are also encompassed.
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