The Desmoinesian Series Granite Wash at Buffalo Wallow Field represents deepwater deposits including slumps, channels, and submarine fan lobes that consist of six major lithofacies as mudstone, interbedded mudstone and sandstone, dark gray muddy sandstone, sandstone with mudstone clasts, fining upward sandstone, and laminated sandstone with mudstone. A combined artificial neural network and well-log cutoff approaches was followed to estimate lithology logs for non-cored wells with 84% accuracy. There are 10 stratigraphic intervals that, from top to bottom, include Marmaton, Caldwell, Cherokee, and Granite Wash A through G. These intervals are bounded by flooding surfaces which are capped by laterally extensive and distinctive mudstone layers. Furthermore, using well logs, a vertical proportion curve, and seismic data a sequence-stratigraphic framework was constructed and system tracts were interpreted that consist of five third-order regressive-transgressive cycles. Detailed 3-D lithological and effective porosity models that were constrained to cores, estimated lithology logs, porosity logs, spatial statistics from variography, and 3-D seismic data illustrate the stratigraphic variability in reservoir characteristics. Sandstone proportion within the study area decreases basinward from southwest to northeast. Moreover, while the sandstone proportion decreases stratigraphically upward, the muddy sandstone increases. In terms of sequence stratigraphy, lowstand and transgressive system tract deposits were combined and they contain a greater amount of sandstone and connectivity when compared to highstand deposits. Highstand deposit thickness increases vertically as well as the muddy sandstone occurrence, which represent more proximal deposits, thus suggesting that there is an overall progradation within the study area.