Many historians have viewed Afro-Mexican blasphemy as an opportunity for resistance against an oppressive system in which enslaved Black people committed sacrilege to appeal to the Mexican Inquisition for reprieve and to verbally rebuke the culture of the masters and overseers who punished them. Recent historians such as Frank Proctor III have countered these assumptions and denounced the ascription of resistance to every action taken by Afro-Mexicans. This study pushes beyond these prior analyses by focusing on creolization evident in Afro-Mexican blasphemy trials by analyzing seven Inquisition cases with defendants from central Mexico. Enslaved Afro-Mexicans’ responses to the circumstances surrounding their imprisonment and subjugation under the absolutist state reveal insight into the process of cultural and social change surrounding their status in colonial Mexico. Given numerous opportunities to present their view of the circumstances, these enslaved men, women, and young adults pleaded to the Inquisition for mercy and performed distinct rituals appealing to the ethos, logos, and pathos of the judges by professing their love of God, their firm belief in Catholic doctrine, and their status as victims of un-Christian-like behavior by masters who failed as virtuous exemplars. Presenting the testimonies of Black, mixed-race, African, and Creole peoples, this study contributes to the wider body of Afro-Mexican religious and sociocultural history. It portrays each case with nuance and will aid future researchers who seek to push beyond discovering agency.