dc.contributor.author | Lamichhane, Gopal | |
dc.contributor.author | Liu, Jing | |
dc.contributor.author | Lee, Su-Jeong | |
dc.contributor.author | Lee, Da-Yeon | |
dc.contributor.author | Zhang, Guolong | |
dc.contributor.author | Kim, Yoo | |
dc.date.accessioned | 2024-01-17T19:46:49Z | |
dc.date.available | 2024-01-17T19:46:49Z | |
dc.date.issued | 2024-01-12 | |
dc.identifier | oksd_lamichhane_curcumin_mitigates_the_high_2024 | |
dc.identifier.citation | Lamichhane, G., Liu, J., Lee, S.-J., Lee, D.-Y., Zhang, G., Kim, Y. (2024). Curcumin mitigates the high-fat high-sugar diet-induced impairment of spatial memory, hepatic metabolism, and the alteration of the gut microbiome in alzheimer’s disease-induced (3xtg-ad) mice. Nutrients, 16(2), pp. 240-240. https://doi.org/10.3390/nu16020240 | |
dc.identifier.uri | https://hdl.handle.net/11244/340120 | |
dc.description.abstract | The escalating prevalence of metabolic diseases and an aging demographic has been correlated with a concerning rise in Alzheimer’s disease (AD) incidence. This study aimed to access the protective effects of curcumin, a bioactive flavonoid from turmeric, on spatial memory, metabolic functions, and the regulation of the gut microbiome in AD-induced (3xTg-AD) mice fed with either a normal chow diet (NCD) or a high-fat high-sugar diet (HFHSD). Our findings revealed an augmented susceptibility of the HFHSD-fed 3xTg-AD mice for weight gain and memory impairment, while curcumin supplementation demonstrated a protective effect against these changes. This was evidenced by significantly reduced body weight gain and improved behavioral and cognitive function in the curcumin-treated group. These improvements were substantiated by diminished fatty acid synthesis, altered cholesterol metabolism, and suppressed adipogenesis-related pathways in the liver, along with modified synaptic plasticity-related pathways in the brain. Moreover, curcumin enriched beneficial gut microbiota, including Oscillospiraceae and Rikenellaceae at the family level, and Oscillibacter, Alistipes, Pseudoflavonifractor, Duncaniella, and Flintibacter at the genus level. The observed alteration in these gut microbiota profiles suggests a potential crosswalk in the liver and brain for regulating metabolic and cognitive functions, particularly in the context of obesity-associated cognitive disfunction, notably AD. | |
dc.format | application/pdf | |
dc.language | en_US | |
dc.publisher | MDPI AG | |
dc.relation.ispartof | Nutrients, 16 (2) | |
dc.relation.uri | http://dx.doi.org/10.3390/nu16020240 | |
dc.rights | This material has been previously published. In the Oklahoma State University Library's institutional repository this version is made available through the open access principles and the terms of agreement/consent between the author(s) and the publisher. The permission policy on the use, reproduction or distribution of the material falls under fair use for educational, scholarship, and research purposes. Contact Digital Resources and Discovery Services at lib-dls@okstate.edu or 405-744-9161 for further information. | |
dc.title | Curcumin mitigates the high-fat high-sugar diet-induced impairment of spatial memory, hepatic metabolism, and the alteration of the gut microbiome in alzheimer’s disease-induced (3xtg-ad) mice | |
dc.date.updated | 2024-01-14T22:33:45Z | |
osu.filename | oksd_lamichhane_curcumin_mitigates_the_high_2024.pdf | |
dc.identifier.doi | 10.3390/nu16020240 | |
dc.description.department | Dept of Animal and Food Sciences | |
dc.description.department | Nutritional Sciences | |
dc.type.genre | Article | |
dc.type.material | Text | |
dc.subject.keywords | food sciences | |
dc.subject.keywords | nutrition and dietetics | |
dc.subject.keywords | clinical sciences | |
dc.subject.keywords | nutrition and dietetics | |
dc.subject.keywords | public health | |
dc.identifier.author | ORCID: 0000-0003-1487-7578 (Lamichhane, Gopal) | |
dc.identifier.author | ORCID: 0000-0003-0819-8982 (Lee, Su-Jeong) | |
dc.identifier.author | ORCID: 0000-0002-4085-0689 (Lee, Da-Yeon) | |
dc.identifier.author | ORCID: 0000-0003-4781-5816 (Zhang, Guolong) | |
dc.identifier.author | ScopusID: 7405270549 (Zhang, Guolong) | |
dc.identifier.author | ORCID: 0000-0002-4525-1319 (Kim, Yoo) | |
dc.identifier.author | ScopusID: 57218459560 | 57687368900 (Kim, Yoo) | |
dc.identifier.essn | 2072-6643 | |