dc.contributor.author | Vicosa Bauermann, Fernando | |
dc.contributor.author | Falkenberg, Shollie | |
dc.contributor.author | Rudd, Jennifer M. | |
dc.contributor.author | Mendes Peter, Cristina | |
dc.contributor.author | Merchioratto, Ingryd | |
dc.contributor.author | Ritchey, Jerry W. | |
dc.contributor.author | Gilliam, John | |
dc.contributor.author | Taylor, Jared | |
dc.contributor.author | Ma, Hao | |
dc.contributor.author | Maggioli, Mayara Fernanda | |
dc.date.accessioned | 2024-01-08T14:30:17Z | |
dc.date.available | 2024-01-08T14:30:17Z | |
dc.date.issued | 2023-12-16 | |
dc.identifier | oksd_bauermann_immune_response_to_influenza_2023 | |
dc.identifier.citation | Vicosa Bauermann, F., Falkenberg, S., Rudd, J., Mendes, C., Merchioratto, I., Ritchey, J., Gilliam, J., Taylor, J., Ma, H., Mendes, Maggioli, M. (2023). Immune responses to influenza D virus in calves previously infected with bovine viral diarrhea virus 2. Viruses, 15(12), 2442. https://doi.org/10.3390/v15122442 | |
dc.identifier.uri | https://hdl.handle.net/11244/340102 | |
dc.description.abstract | Bovine viral diarrhea virus (BVDV) induces immunosuppression and thymus depletion in calves. This study explores the impact of prior BVDV-2 exposure on the subsequent immune response to influenza D virus (IDV). Twenty 3-week-old calves were divided into four groups. Calves in G1 and G3 were mock-treated on day 0, while calves in G2 and G4 received BVDV. Calves in G1 (mock) and G2 (BVDV) were necropsied on day 13 post-infection. IDV was inoculated on day 21 in G3 calves (mock + IDV) and G4 (BVDV + IDV) and necropsy was conducted on day 42. Pre-exposed BVDV calves exhibited prolonged and increased IDV shedding in nasal secretions. An approximate 50% reduction in the thymus was observed in acutely infected BVDV calves (G2) compared to controls (G1). On day 42, thymus depletion was observed in two calves in G4, while three had normal weight. BVDV-2-exposed calves had impaired CD8 T cell proliferation after IDV recall stimulation, and the α/β T cell impairment was particularly evident in those with persistent thymic atrophy. Conversely, no difference in antibody levels against IDV was noted. BVDV-induced thymus depletion varied from transient to persistent. Persistent thymus atrophy was correlated with weaker T cell proliferation, suggesting correlation between persistent thymus atrophy and impaired T cell immune response to subsequent infections. | |
dc.format | application/pdf | |
dc.language | en_US | |
dc.publisher | MDPI | |
dc.relation.uri | https://www.ncbi.nlm.nih.gov/pubmed/38140683 | |
dc.rights | This material has been previously published. In the Oklahoma State University Library's institutional repository this version is made available through the open access principles and the terms of agreement/consent between the author(s) and the publisher. The permission policy on the use, reproduction or distribution of the material falls under fair use for educational, scholarship, and research purposes. Contact Digital Resources and Discovery Services at lib-dls@okstate.edu or 405-744-9161 for further information. | |
dc.subject.mesh | animals | |
dc.subject.mesh | cattle | |
dc.subject.mesh | diarrhea virus 2, bovine viral | |
dc.subject.mesh | deltainfluenzavirus | |
dc.subject.mesh | bovine virus diarrhea-mucosal disease | |
dc.subject.mesh | diarrhea viruses, bovine viral | |
dc.subject.mesh | immunity | |
dc.subject.mesh | atrophy | |
dc.subject.mesh | diarrhea virus 1, bovine viral | |
dc.subject.mesh | antibodies, viral | |
dc.title | Immune responses to influenza D virus in calves previously infected with bovine viral diarrhea virus 2 | |
dc.date.updated | 2024-01-04T22:37:15Z | |
osu.filename | oksd_bauermann_immune_response_to_influenza_2023.pdf | |
dc.identifier.doi | 10.3390/v15122442 | |
dc.description.department | Veterinary Pathobiology | |
dc.description.department | Dean of Veterinary Medicine | |
dc.type.genre | Article | |
dc.type.material | Text | |
dc.subject.keywords | microbiology | |
dc.subject.keywords | biological sciences | |
dc.subject.keywords | emerging infectious diseases | |
dc.subject.keywords | pneumonia & influenza | |
dc.subject.keywords | influenza | |
dc.subject.keywords | infectious diseases | |
dc.subject.keywords | vaccine related | |
dc.subject.keywords | factors relating to the physical environment | |
dc.subject.keywords | aetiology | |
dc.subject.keywords | infection | |
dc.subject.keywords | bovine viral diarrhea virus | |
dc.subject.keywords | immune responses | |
dc.subject.keywords | influenza d virus | |
dc.subject.keywords | pathogenesis | |
dc.subject.keywords | thymus | |
dc.subject.keywords | microbiology | |
dc.identifier.author | ORCID: 0000-0003-3891-1152 (Vicosa Bauermann, Fernando) | |
dc.identifier.author | ScopusID: 15135127900 (Vicosa Bauermann, Fernando) | |
dc.identifier.author | ORCID: 0000-0002-4532-3458 (Rudd, Jennifer) | |
dc.identifier.author | ScopusID: 57200207592 (Rudd, Jennifer) | |
dc.identifier.author | ORCID: 0000-0002-7484-085X (Taylor, Jared) | |
dc.identifier.author | ScopusID: 7405407145 (Taylor, Jared) | |
dc.identifier.author | ORCID: 0000-0003-0307-4673 (Ritchey, Jerry) | |
dc.identifier.author | ScopusID: 7006378376 (Ritchey, Jerry) | |
dc.identifier.author | ORCID: 0000-0003-1234-3257 (Maggioli, Mayara) | |
dc.identifier.author | ScopusID: 56046575600 (Maggioli, Mayara) | |