Trans-rectal ultrasound-coupled near-infrared optical tomography of the prostate. Part II: Experimental demonstration
Date
2008-10-15Author
Jiang, Zhen
Piao, Daqing
Xu, Guan
Ritchey, Jerry W.
Reed Holyoak, G
Bartels, Kenneth E.
Bunting, Charles F.
Slobodov, Gennady
Krasinki, Jerzy S.
Metadata
Show full item recordAbstract
We demonstrate trans-rectal optical tomography of the prostate using an endo-rectal near-infrared (NIR) applicator integrated with a transrectal ultrasound (TRUS) probe. The endo-rectal NIR applicator incorporated a design presented in our previously reported work. A continuous-wave NIR optical tomography system is combined with a commercial US scanner to form the dual-modality imager. Sagittal transrectal imaging is performed concurrently by endo-rectal NIR and TRUS. The TRUS ensures accurate positioning of the NIR applicator as well as guides NIR image reconstruction using the spatial prior of the target. The use of a condom, which is standard for TRUS, is found to have minimal effect on trans-rectal NIR imaging. Tests on avian tissues validates that NIR imaging can recover the absorption contrast of a target, and its accuracy is improved when the TRUS spatial prior is incorporated. Trans-rectal NIR/US imaging of a healthy canine prostate in situ is reported.
Citation
Jiang, Z., Piao, D., ... Krasinki, J.S. (2008). Trans-rectal ultrasound-coupled near-infrared optical tomography of the prostate. Part II: Experimental demonstration. Optics Express, 16(22), 17505-17520. https://doi.org/10.1364/OE.16.017505