dc.contributor.author | Piao, Daqing | |
dc.contributor.author | Hawxby, Alan | |
dc.contributor.author | Wright, Harlan | |
dc.contributor.author | Rubin, Erin M. | |
dc.date.accessioned | 2023-07-06T21:37:01Z | |
dc.date.available | 2023-07-06T21:37:01Z | |
dc.date.issued | 2018-08-29 | |
dc.identifier | oksd_piao_perspective_review_on_solid_2018 | |
dc.identifier.citation | Piao, D., Hawxby, A., Wright, H., Rubin, E.M. (2018). Perspective review on solid-organ transplant: Needs in point-of-care optical biomarkers. Journal of Biomedical Optics, 23(8), 080601-080601. https://doi.org/10.1117/1.JBO.23.8.080601 | |
dc.identifier.issn | 1083-3668 | |
dc.identifier.uri | https://hdl.handle.net/11244/337908 | |
dc.description.abstract | Solid-organ transplant is one of the most complex areas of modern medicine involving surgery. There are challenging opportunities in solid-organ transplant, specifically regarding the deficiencies in pathology workflow or gaps in pathology support, which may await alleviations or even de novo solutions, by means of point-of-care, or point-of-procedure optical biomarkers. Focusing the discussions of pathology workflow on donor liver assessment, we analyze the undermet need for intraoperative, real-time, and nondestructive assessment of the donor injuries (such as fibrosis, steatosis, and necrosis) that are the most significant predictors of post-transplant viability. We also identify an unmet need for real-time and nondestructive characterization of ischemia or irreversible injuries to the donor liver, earlier than appearing on morphological histology examined with light microscopy. Point-of-procedure laparoscopic optical biomarkers of liver injuries and tissue ischemia may also facilitate post-transplant management that is currently difficult for or devoid of pathological consultation due to lack of tools. The potential and pitfalls of point-of-procedure optical biomarkers for liver assessment are exemplified in breadth for steatosis. The more general and overarching challenges of point-of-procedure optical biomarkers for liver transplant pathology, including the shielding effect of the liver capsule that was quantitated only recently, are projected. The technological and presentational benchmarks that a candidate technology of point-of-procedure optical biomarkers for transplant pathology must demonstrate to motivate clinical translation are also foreseen. | |
dc.format | application/pdf | |
dc.language | en_US | |
dc.publisher | SPIE, the international society for optics and photonics | |
dc.relation.ispartof | Journal of Biomedical Optics, 23 (8) | |
dc.relation.uri | https://www.ncbi.nlm.nih.gov/pubmed/30160078 | |
dc.rights | This material has been previously published. In the Oklahoma State University Library's institutional repository this version is made available through the open access principles and the terms of agreement/consent between the author(s) and the publisher. The permission policy on the use, reproduction or distribution of the material falls under fair use for educational, scholarship, and research purposes. Contact Digital Resources and Discovery Services at lib-dls@okstate.edu or 405-744-9161 for further information. | |
dc.title | Perspective review on solid-organ transplant: Needs in point-of-care optical biomarkers | |
dc.date.updated | 2023-07-02T13:28:43Z | |
dc.note | open access status: Gold OA | |
dc.identifier.doi | 10.1117/1.JBO.23.8.080601 | |
dc.description.department | Electrical and Computer Engineering | |
dc.type.genre | Article | |
dc.type.material | Text | |
dc.subject.keywords | biomedical and clinical sciences | |
dc.subject.keywords | clinical sciences | |
dc.subject.keywords | organ transplantation | |
dc.subject.keywords | digestive diseases | |
dc.subject.keywords | liver disease | |
dc.subject.keywords | chronic liver disease and cirrhosis | |
dc.subject.keywords | transplantation | |
dc.subject.keywords | detection, screening and diagnosis | |
dc.subject.keywords | discovery and preclinical testing of markers and technologies | |
dc.subject.keywords | good health and well being | |
dc.subject.keywords | fibrosis | |
dc.subject.keywords | optical biomarker | |
dc.subject.keywords | optical spectroscopy | |
dc.subject.keywords | point-of-care | |
dc.subject.keywords | solid-organ transplant | |
dc.subject.keywords | steatosis | |
dc.subject.keywords | optical physics | |
dc.subject.keywords | optics | |
dc.subject.keywords | ophthalmology and optometry | |
dc.subject.keywords | biomedical engineering | |
dc.subject.keywords | atomic, molecular and optical physics | |
dc.subject.keywords | biomarkers | |
dc.subject.keywords | fatty liver | |
dc.subject.keywords | humans | |
dc.subject.keywords | liver | |
dc.subject.keywords | liver cirrhosis | |
dc.subject.keywords | liver transplantation | |
dc.subject.keywords | optical imaging | |
dc.subject.keywords | point-of-care systems | |
dc.subject.keywords | transplants | |
dc.identifier.author | ORCID: 0000-0003-0922-6885 (Piao, D) | |
dc.identifier.author | ScopusID: 7005153312 | 57220465193 (Piao, D) | |
dc.identifier.author | ResearcherID: I-1341-2013 (Piao, D) | |
dc.identifier.author | ScopusID: 6507412061 (Hawxby, A) | |
dc.identifier.author | ScopusID: 7202463116 (Wright, H) | |
dc.identifier.author | ScopusID: 57202237829 (Rubin, EM) | |
dc.identifier.essn | 1560-2281 | |