dc.contributor.author | He, Jie | |
dc.contributor.author | Wilson, Brian C. | |
dc.contributor.author | Piao, Daqing | |
dc.contributor.author | Weersink, Robert | |
dc.date.accessioned | 2023-07-06T20:57:01Z | |
dc.date.available | 2023-07-06T20:57:01Z | |
dc.date.issued | 2014-08-06 | |
dc.identifier | oksd_he_diffuse_optical_tomography_2014 | |
dc.identifier.citation | He, J., Wilson, B.C., Piao, D., Weersink, R. (2014). Diffuse optical tomography to monitor the photocoagulation front during interstitial photothermal therapy: Numerical simulations and measurements in tissue-simulating phantoms. Photonics and Lasers in Medicine, 3(3), 241-254. https://doi.org/10.1515/plm-2014-0011 | |
dc.identifier.issn | 2193-0635 | |
dc.identifier.uri | https://hdl.handle.net/11244/337903 | |
dc.description.abstract | Near-infrared interstitial photothermal therapy (PTT) is currently undergoing clinical trials as an alternative to watchful waiting or radical treatments in patients with low/intermediate-risk focal prostate cancer. Currently, magnetic resonance imaging (MRI)-based thermography is used to monitor thermal energy delivery and determine indirectly the completeness of the target tumor destruction while avoiding damage to adjacent normal tissues, particularly the rectal wall. As an alternative, transrectal diffuse optical tomography (TRDOT) is being developed to image directly the photocoagulation boundary based on the changes in tissue optical properties, particularly scattering. An established diffusion-theory finite-element software platform was used to perform forward simulations to determine the sensitivity of changes in the optical signal resulting from a growing coagulated lesion with optical scattering contrast, for varying light source-detector separations in both longitudinal and transverse imaging geometries. The simulations were validated experimentally in tissue-simulating phantoms using an existing continuous-wave TRDOT system, in a configuration that is representative of one potential intended clinical use. This provides critical guidance for the optimum design of the transrectal applicator probe, in terms of achieving maximum sensitivity to the presence of the coagulation boundary and, consequently, the highest accuracy in determining the boundary location relative to the rectal wall. | |
dc.format | application/pdf | |
dc.language | en_US | |
dc.publisher | De Gruyter | |
dc.relation.ispartof | Photonics and Lasers in Medicine, 3 (3) | |
dc.rights | This material has been previously published. In the Oklahoma State University Library's institutional repository this version is made available through the open access principles and the terms of agreement/consent between the author(s) and the publisher. The permission policy on the use, reproduction or distribution of the material falls under fair use for educational, scholarship, and research purposes. Contact Digital Resources and Discovery Services at lib-dls@okstate.edu or 405-744-9161 for further information. | |
dc.title | Diffuse optical tomography to monitor the photocoagulation front during interstitial photothermal therapy: Numerical simulations and measurements in tissue-simulating phantoms | |
dc.date.updated | 2023-07-02T13:38:50Z | |
dc.note | open access status: Bronze OA | |
dc.identifier.doi | 10.1515/plm-2014-0011 | |
dc.description.department | Electrical and Computer Engineering | |
dc.type.genre | Article | |
dc.type.material | Text | |
dc.subject.keywords | physical sciences | |
dc.subject.keywords | biomedical and clinical sciences | |
dc.subject.keywords | clinical sciences | |
dc.subject.keywords | oncology and carcinogenesis | |
dc.subject.keywords | biomedical imaging | |
dc.subject.keywords | bioengineering | |
dc.subject.keywords | cancer | |
dc.subject.keywords | detection, screening and diagnosis | |
dc.subject.keywords | discovery and preclinical testing of markers and technologies | |
dc.subject.keywords | good health and well being | |
dc.identifier.author | ScopusID: 55735777100 (He, J) | |
dc.identifier.author | ScopusID: 57203030243 (Wilson, BC) | |
dc.identifier.author | ORCID: 0000-0003-0922-6885 (Piao, D) | |
dc.identifier.author | ScopusID: 7005153312 | 57220465193 (Piao, D) | |
dc.identifier.author | ResearcherID: I-1341-2013 (Piao, D) | |
dc.identifier.author | ScopusID: 6602724577 (Weersink, R) | |
dc.identifier.essn | 2193-0643 | |