dc.contributor.author | Neyrolles, Olivier | |
dc.contributor.author | Wolschendorf, Frank | |
dc.contributor.author | Mitra, Avishek | |
dc.contributor.author | Niederweis, Michael | |
dc.date.accessioned | 2023-02-16T16:47:59Z | |
dc.date.available | 2023-02-16T16:47:59Z | |
dc.date.issued | 2015-03 | |
dc.identifier.citation | Neyrolles, O., Wolschendorf, F., Mitra, A., Niederweis, M. (2015). Mycobacteria, metals, and the macrophage. Immunological Reviews, 264(1), pp. 249-263. https://doi.org/10.1111/imr.12265 | |
dc.identifier.issn | 0105-2896 | |
dc.identifier.uri | https://hdl.handle.net/11244/337041 | |
dc.description.abstract | Mycobacterium tuberculosis is a facultative intracellular pathogen that thrives inside host macrophages. A key trait of M. tuberculosis is to exploit and manipulate metal cation trafficking inside infected macrophages to ensure survival and replication inside the phagosome. Here, we describe the recent fascinating discoveries that the mammalian immune system responds to infections with M. tuberculosis by overloading the phagosome with copper and zinc, two metals which are essential nutrients in small quantities but are toxic in excess. M. tuberculosis has developed multi-faceted resistance mechanisms to protect itself from metal toxicity including control of uptake, sequestration inside the cell, oxidation, and efflux. The host response to infections combines this metal poisoning strategy with nutritional immunity mechanisms that deprive M. tuberculosis from metals such as iron and manganese to prevent bacterial replication. Both immune mechanisms rely on the translocation of metal transporter proteins to the phagosomal membrane during the maturation process of the phagosome. This review summarizes these recent findings and discusses how metal-targeted approaches might complement existing TB chemotherapeutic regimens with novel anti-infective therapies. | |
dc.format | application/pdf | |
dc.language | eng | |
dc.publisher | Wiley | |
dc.relation.ispartof | Immunological Reviews, 264 (1) | |
dc.relation.uri | https://www.ncbi.nlm.nih.gov/pubmed/25703564 | |
dc.relation.uri | http://dx.doi.org/10.1111/imr.12265 | |
dc.rights | This material has been previously published. In the Oklahoma State University Library's institutional repository this version is made available through the open access principles and the terms of agreement/consent between the author(s) and the publisher. The permission policy on the use, reproduction or distribution of the material falls under fair use for educational, scholarship, and research purposes. Contact Digital Resources and Discovery Services at lib-dls@okstate.edu or 405-744-9161 for further information. | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Antitubercular Agents | |
dc.subject.mesh | Copper | |
dc.subject.mesh | Host-Pathogen Interactions | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Immunity, Innate | |
dc.subject.mesh | Iron | |
dc.subject.mesh | Macrophages | |
dc.subject.mesh | Metals | |
dc.subject.mesh | Mycobacterium tuberculosis | |
dc.subject.mesh | Phagosomes | |
dc.subject.mesh | Tuberculosis | |
dc.subject.mesh | Virulence | |
dc.subject.mesh | Zinc | |
dc.title | Mycobacteria, metals, and the macrophage | |
dc.date.updated | 2023-02-15T23:01:05Z | |
dc.note | open access status: Green OA | |
dc.identifier.doi | 10.1111/imr.12265 | |
dc.description.department | Microbiology and Molecular Genetics | |
dc.type.genre | Article | |
dc.type.material | Text | |
dc.subject.keywords | HIV/AIDS | |
dc.subject.keywords | Biodefense | |
dc.subject.keywords | Rare Diseases | |
dc.subject.keywords | Orphan Drug | |
dc.subject.keywords | Antimicrobial Resistance | |
dc.subject.keywords | Tuberculosis | |
dc.subject.keywords | Prevention | |
dc.subject.keywords | Infectious Diseases | |
dc.subject.keywords | Vaccine Related | |
dc.subject.keywords | Biotechnology | |
dc.subject.keywords | Emerging Infectious Diseases | |
dc.subject.keywords | Factors relating to the physical environment | |
dc.subject.keywords | Biological and endogenous factors | |
dc.subject.keywords | Aetiology | |
dc.subject.keywords | Infection | |
dc.subject.keywords | Good Health and Well Being | |
dc.subject.keywords | copper | |
dc.subject.keywords | innate immunity | |
dc.subject.keywords | iron | |
dc.subject.keywords | manganese | |
dc.subject.keywords | nutritional immunity | |
dc.subject.keywords | phagosome | |
dc.subject.keywords | poisoning | |
dc.subject.keywords | zinc | |
dc.subject.keywords | Immunology | |
dc.relation.oaurl | https://pubmed.ncbi.nlm.nih.gov/25703564/ | |
dc.identifier.author | ORCID: 0000-0003-0243-2045 (Mitra, Avishek) | |
dc.identifier.essn | 1600-065X | |