dc.contributor.advisor | Singh, Shanteri | |
dc.contributor.advisor | Duerfeldt, Adam | |
dc.contributor.author | Gardner, Jessica Jeanora Hayes | |
dc.date.accessioned | 2022-05-10T16:05:16Z | |
dc.date.available | 2022-05-10T16:05:16Z | |
dc.date.issued | 2022-05-13 | |
dc.identifier.uri | https://hdl.handle.net/11244/335667 | |
dc.description.abstract | The overall aim of this work is to contribute to molecular design strategies for early lead development while probing structure-activity relationships via the design and synthesis of small molecules. This dissertation will tell three distinct stories: (1) exploitation of CpxRA as a target for virulence modulation in Gram-negative bacteria, (2) work towards the total synthesis of Picrasidine natural product family members, and (3) the rational design and synthesis of SARS-CoV-2 main protease inhibitors. | en_US |
dc.language | en_US | en_US |
dc.subject | Virulence | en_US |
dc.subject | Protease Inhibitors | en_US |
dc.subject | Natural Products | en_US |
dc.subject | Synthetic Chemistry | en_US |
dc.title | Small molecule design strategies for probing structure-activity relationships: bacterial virulence modulation via CpxRA, the total synthesis of Picrasma alkaloids, and coronavirus main protease inhibitors | en_US |
dc.contributor.committeeMember | Cichewicz, Robert | |
dc.contributor.committeeMember | O'Rear, Edgar | |
dc.contributor.committeeMember | Glatzhofer, Daniel | |
dc.date.manuscript | 2022 | |
dc.thesis.degree | Ph.D. | en_US |
ou.group | Dodge Family College of Arts and Sciences:: Department of Chemistry and Biochemistry | en_US |