dc.contributor.author | Beier, John C. | |
dc.contributor.author | Davis, Jonathan R. | |
dc.contributor.author | Vaughan, Jefferson A. | |
dc.contributor.author | Noden, Bruce H. | |
dc.contributor.author | Beier, Magda S. | |
dc.date.accessioned | 2022-04-12T13:48:22Z | |
dc.date.available | 2022-04-12T13:48:22Z | |
dc.date.issued | 1991 | |
dc.identifier | oksd_noden_quantitationofplasmodiumfalciparum_1991 | |
dc.identifier.citation | Beier, J. C., Davis, J. R., Vaughan, J. A., Noden, B. H., & Beier, M. S. (1991). Quantitation of Plasmodium falciparum sporozoites transmitted in vitro by experimentally infected Anopheles gambiae and Anopheles stephensi. American Journal of Tropical Medicine and Hygiene, 44(5), pp. 564-570. https://doi.org/10.4269/ajtmh.1991.44.564 | |
dc.identifier.uri | https://hdl.handle.net/11244/335166 | |
dc.description.abstract | The frequency and numbers of Plasmodium falciparum sporozoites transmitted in vitro and corresponding sporozoite loads were determined for experimentally infected Anopheles gambiae and An. stephensi. Geometric mean (GM) sporozoite loads in three experiments ranged from 808 to 13,905 for An. gambiae and from 6,608 to 17,702 for An. stephensi. A total of 44.1% of 68 infected An. gambiae and 49.2% of 63 infected An. stephensi transmitted sporozoites in vitro. The GM number of sporozoites transmitted was 4.5 for An. gambiae and 5.4 for An. stephensi. Overall, 86.9% of the mosquitoes transmitted from one to 25 sporozoites, and only 6.6% transmitted over 100 sporozoites (maximum = 369). Sporozoite loads were not a useful predictor of potential sporozoite transmission. Despite higher sporozoite loads, the numbers of sporozoites transmitted in vitro by the experimentally infected mosquitoes were similar to estimates obtained, using the same techniques, for naturally infected An. gambiae in western Kenya. The low but highly variable numbers of sporozoites transmitted in vitro by mosquitoes used in malaria vaccine challenge studies appears to be a reasonable simulation of natural sporozoite transmission. | |
dc.format | application/pdf | |
dc.language | en_US | |
dc.publisher | American Society of Tropical Medicine and Hygiene | |
dc.relation.ispartof | American Journal of Tropical Medicine and Hygiene, 44 (5) | |
dc.relation.uri | https://www.ncbi.nlm.nih.gov/pubmed/2063960 | |
dc.rights | This material has been previously published. In the Oklahoma State University Library's institutional repository this version is made available through the open access principles and the terms of agreement/consent between the author(s) and the publisher. The permission policy on the use, reproduction or distribution of the material falls under fair use for educational, scholarship, and research purposes. Contact Digital Resources and Discovery Services at lib-dls@okstate.edu or 405-744-9161 for further information. | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Anopheles | |
dc.subject.mesh | Insect Vectors | |
dc.subject.mesh | Plasmodium falciparum | |
dc.title | Quantitation of Plasmodium falciparum sporozoites transmitted in vitro by experimentally infected Anopheles gambiae and Anopheles stephensi | |
dc.date.updated | 2022-04-07T15:19:43Z | |
osu.filename | oksd_noden_quantitationofplasmodiumfalciparum_1991.pdf | |
dc.description.peerreview | Peer reviewed | |
dc.identifier.doi | 10.4269/ajtmh.1991.44.564 | |
dc.description.department | Entomology and Plant Pathology | |
dc.type.genre | Article | |
dc.type.material | Text | |
dc.subject.keywords | Rare Diseases | |
dc.subject.keywords | Prevention | |
dc.subject.keywords | Infectious Diseases | |
dc.subject.keywords | HIV/AIDS | |
dc.subject.keywords | Malaria | |
dc.subject.keywords | Vector-Borne Diseases | |
dc.subject.keywords | 2.2 Factors relating to the physical environment | |
dc.subject.keywords | Infection | |
dc.subject.keywords | 3 Good Health and Well Being | |
dc.subject.keywords | 11 Medical and Health Sciences | |
dc.subject.keywords | Tropical Medicine | |
dc.identifier.author | ScopusID: 7102003162 (Beier, JC) | |
dc.identifier.author | ScopusID: 7405963291 (Davis, JR) | |
dc.identifier.author | ScopusID: 7202772214 (Vaughan, JA) | |
dc.identifier.author | ORCID: 0000-0002-0096-370X (Noden, BH) | |
dc.identifier.author | ScopusID: 6601968347 (Noden, BH) | |
dc.identifier.author | ScopusID: 7006044128 (Beier, MS) | |