dc.contributor.author | Beier, John C. | |
dc.contributor.author | Vaughan, Jefferson A. | |
dc.contributor.author | Madani, Aya | |
dc.contributor.author | Noden, Bruce H. | |
dc.date.accessioned | 2022-04-12T13:46:38Z | |
dc.date.available | 2022-04-12T13:46:38Z | |
dc.date.issued | 1992 | |
dc.identifier | oksd_noden_plasmodiumfalciparumrelease_1992 | |
dc.identifier.citation | Beier, J. C., Vaughan, J. A., Madani, A., & Noden, B. H. (1992). Plasmodium falciparum: Release of circumsporozoite protein by sporozoites in the mosquito vector. Experimental Parasitology, 75(2), pp. 248-256. https://doi.org/10.1016/0014-4894(92)90185-D | |
dc.identifier.uri | https://hdl.handle.net/11244/335156 | |
dc.description.abstract | The release of circumsporozoite (CS) protein by Plasmodium falciparum sporozoites was investigated to identify factors regulating this process within infected Anopheles gambiae mosquitoes. The potential for sporozoites to release CS protein in vitro was not dependent upon their site-specific developmental stage (i.e., mature oocysts, hemolymph, salivary glands), their duration in the vector, or their exposure to mosquito-derived components such as salivary glands or hemolymph. The capacity of sporozoites to release CS protein was depressed by mosquito blood feeding during periods of sporozoite migration to the salivary glands, but the effect was only temporary and those sporozoites already in the glands were not affected. Free CS protein in the salivary glands was present in 93.3% of 45 infective mosquitoes. Sporozoites from these same, individual mosquitoes were also tested in vitro for CS protein release. In both cases, the amount of soluble CS protein increased as a function of sporozoite density but the total amount of CS protein per sporozoite became progressively less with increasing numbers of sporozoites. Further experiments showed that sporozoite contact with increasing amounts of soluble CS protein caused a down-regulation of CS protein release. Thus, a primary factor regulating the production and release of CS protein by sporozoites is their contact with soluble CS protein within the mosquito. | |
dc.format | application/pdf | |
dc.language | en_US | |
dc.publisher | Elsevier BV | |
dc.relation.ispartof | Experimental Parasitology, 75 (2) | |
dc.relation.uri | https://www.ncbi.nlm.nih.gov/pubmed/1516673 | |
dc.rights | This material has been previously published. In the Oklahoma State University Library's institutional repository this version is made available through the open access principles and the terms of agreement/consent between the author(s) and the publisher. The permission policy on the use, reproduction or distribution of the material falls under fair use for educational, scholarship, and research purposes. Contact Digital Resources and Discovery Services at lib-dls@okstate.edu or 405-744-9161 for further information. | |
dc.subject.mesh | Animals | |
dc.subject.mesh | Anopheles | |
dc.subject.mesh | Antigens, Protozoan | |
dc.subject.mesh | Hemolymph | |
dc.subject.mesh | Insect Vectors | |
dc.subject.mesh | Plasmodium falciparum | |
dc.subject.mesh | Protozoan Proteins | |
dc.subject.mesh | Salivary Glands | |
dc.subject.mesh | Temperature | |
dc.subject.mesh | Time Factors | |
dc.title | Plasmodium falciparum: Release of circumsporozoite protein by sporozoites in the mosquito vector | |
dc.date.updated | 2022-04-07T15:18:28Z | |
osu.filename | oksd_noden_plasmodiumfalciparumrelease_1992.pdf | |
dc.description.peerreview | Peer reviewed | |
dc.identifier.doi | 10.1016/0014-4894(92)90185-D | |
dc.description.department | Entomology and Plant Pathology | |
dc.type.genre | Article | |
dc.type.material | Text | |
dc.subject.keywords | Rare Diseases | |
dc.subject.keywords | Infectious Diseases | |
dc.subject.keywords | Vector-Borne Diseases | |
dc.subject.keywords | Malaria | |
dc.subject.keywords | Prevention | |
dc.subject.keywords | 2.2 Factors relating to the physical environment | |
dc.subject.keywords | 3 Good Health and Well Being | |
dc.subject.keywords | 0605 Microbiology | |
dc.subject.keywords | 0707 Veterinary Sciences | |
dc.subject.keywords | Mycology & Parasitology | |
dc.identifier.author | ScopusID: 7102003162 (Beier, JC) | |
dc.identifier.author | ScopusID: 7202772214 (Vaughan, JA) | |
dc.identifier.author | ScopusID: 15035843900 (Madani, A) | |
dc.identifier.author | ORCID: 0000-0002-0096-370X (Noden, BH) | |
dc.identifier.author | ScopusID: 6601968347 (Noden, BH) | |