OU - MCTE 3151 Molecular, Cellular and Tissue Engineering Lab

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https://hdl.handle.net/11244/331258
This collection of papers is an ongoing product by students of the MCTE 3151 Molecular, Cellular and Tissue Engineering Lab. Every semester, as a part of the lab, students do a final lab project and write a full article including abstract, introduction, results, and discussion. These endeavors are supervised by Dr. Breen, instructor of the class, and are curated and prepared for public release by instructional team member Seren Hamsici.

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    Diffusion Through Hydrospheres: Drug Release Model
    (2022) Abousleiman, Ghainaa
    Hydrogels are commonly used as a drug delivery model due to their biocompatibility and mechanical properties. It is important to model drug delivery to gain accurate predictions of how a drug will release into the body. These models help to maximize drug efficacy and safety. The drug release rate is primarily dependent on the rate at which the drug will diffuse out of its encapsulation. Several factors affect the drug release rate of a drug such as a temperature, pH, drug molecule size, surface area of the tablet, etc. To test some of these factors, in this experiment, alginate hydrophores of various sizes are loaded with being loaded with two different molecules. Each size of alginate hydrospheres will be loaded with either BSA or methylene blue. The factors affecting release rate are the surface area to volume ratio of the alginate hydrospheres, and the size of the molecule itself. As the small hydrospheres have a larger surface area to volume ratio they had a faster diffusion rate than the larger hydrospheres. In addition to this, BSA diffused slower than methylene blue as it had a larger molecular weight.