Development of tools to accelerate and advance modeling disease progression

Abstract

Disease pathology emerges from complex interactions at multiple scales including the cellular level, tissue level, and organ level. Multiscale modeling seeks to capture emergent phenomena by coupling models of differing spatial and temporal scales. Multiscale modeling is a powerful tool for modeling disease progression, but this power comes at the cost of great complexity and development time. The primary objective of this thesis is to develop tools that help make multiscale models in less time. The tools developed in this work are a virtual kidney currently in development, a model converter, and a method for producing simulation geometry.