| dc.date.accessioned | 2021-03-08T19:31:58Z | |
| dc.date.available | 2021-03-08T19:31:58Z | |
| dc.date.issued | 2020-11-24 | |
| dc.identifier.uri | https://hdl.handle.net/11244/329017 | |
| dc.description.abstract | Highly antigenic yet safe vaccines against diseases caused by Paramyxoviridae viruses such as respiratory syncytial virus (RSV) are provided. The vaccines comprise attenuated Paramyxoviridae viruses with high antigenicity but which display impaired cell-to-cell transmission as a result of genetic manipulation of the gene encoding the matrix (M) protein. In the viruses, the M protein is absent or mutated to a less active form. Screening or assay systems and methods for evaluating the infectivity of mutant M proteins and for identifying suitable M candidates for live-attenuated vaccine virus and VLP production, are also provided. | |
| dc.format | application/pdf | |
| dc.format.extent | 61 pages | |
| dc.language | en_US | |
| dc.publisher | U.S. Patent and Trademark Office | |
| dc.title | Engineered respiratory syncytial viruses with control of cell-to-cell virus transmission for enhanced safety of live virus vaccines | |
| dc.type | Text | |
| osu.filename | pat10844357.pdf | |
| osu.accesstype | Open Access | |
| dc.type.genre | Patent | |
| dc.contributor.inventor | Oomens, Antonius G. P. | |
| dc.identifier.patentID | 10844357 | |
| dc.date.filed | 2011-06-01 | |
| dc.contributor.assignee | Board of Regents/Oklahoma State University and the A & M Colleges | |
| dc.subject.cpcclasses | C07K 14/005 (20130101) | |
| dc.subject.cpcclasses | C12N 7/00 (20130101) | |
| dc.subject.cpcclasses | C12Q 1/06 (20130101) | |
| dc.subject.cpcclasses | A61K 2039/5254 (20130101) | |
| dc.subject.cpcclasses | C12N 2760/18562 (20130101) | |
| dc.subject.cpcclasses | C12N 2760/18511 (20130101) | |
| dc.subject.cpcclasses | A61K 2039/5258 (20130101) | |
| dc.subject.cpcclasses | C12N 2760/18522 (20130101) | |
| dc.subject.cpcclasses | C12N 2760/18534 (20130101) | |
| dc.subject.cpcclasses | G01N 2333/115 (20130101) | |
| dc.subject.cpcclasses | C12N 2760/18523 (20130101) | |
| dc.subject.cpcclasses | G01N 2500/00 (20130101) | |
