Systemic oppression is evident in health care institutions that can manifest as unfair treatment and disenfranchisement toward marginalized communities. The study examined the predictive relationship health care discrimination and connection with a health care provider has on health-related quality of life, depression, anxiety, trauma, and health care underutilization. Data was collected from a diverse sample of 423 participants. The findings indicate that discrimination is a better predictor that connection for health-related quality of life, mental health outcomes, and health care underutilization, especially when looking exploring the experiences of people of color. Practical implications, clinical implications, and future directions are examined while underscoring the detrimental impacts of discrimination in physical and mental health care settings.