dc.contributor.author | Tayebi, Lobat | |
dc.contributor.author | Parikh, Atul | |
dc.contributor.author | Vashaee, Daryoosh | |
dc.date.accessioned | 2019-09-25T18:24:42Z | |
dc.date.available | 2019-09-25T18:24:42Z | |
dc.date.issued | 2013-02-08 | |
dc.identifier | oksd_tayebi_interlamellaror_2013 | |
dc.identifier.citation | Tayebi, L., Parikh, A., & Vashaee, D. (2013). Interlamellar organization of phase separated domains in multi-component lipid multilayers: Energetic considerations. International Journal of Molecular Sciences, 14(2), 3824-3833. https://doi.org/10.3390/ijms14023824 | |
dc.identifier.uri | https://hdl.handle.net/11244/321438 | |
dc.description.abstract | A recent experimental study [1] has demonstrated the alignment of phase separated domains across hundreds of bilayer units in multicomponent stacked lipid bilayers. The origin of this alignment is the interlamellar coupling of laterally phase separated domains. Here, we develop a theoretical model that presents the energetics description of this phenomenon based on the minimization of the free energy of the system. Specifically, we use solution theory to estimate the competition between energy and entropy in different stacking configurations. The model furnishes an elemental phase diagram, which maps the domain distributions in terms of the strength of the intra- and inter-layer interactions and estimates the value of inter-layer coupling for complete alignment of domains in the stacks of five and ten bilayers. The area fraction occupied by co-existing phases was calculated for the system of the minimum free energy, which showed a good agreement with experimental observations. | |
dc.format | application/pdf | |
dc.language | en_US | |
dc.publisher | MDPI | |
dc.rights | This material has been previously published. In the Oklahoma State University Library's institutional repository this version is made available through the open access principles and the terms of agreement/consent between the author(s) and the publisher. The permission policy on the use, reproduction or distribution of the material falls under fair use for educational, scholarship, and research purposes. Contact Digital Resources and Discovery Services at lib-dls@okstate.edu or 405-744-9161 for further information. | |
dc.title | Interlamellar organization of phase separated domains in multi-component lipid multilayers: Energetic considerations | |
osu.filename | oksd_tayebi_interlamellaror_2013.pdf | |
dc.description.peerreview | Peer reviewed | |
dc.identifier.doi | 10.3390/ijms14023824 | |
dc.description.department | Chemical Engineering | |
dc.type.genre | Article | |
dc.type.material | Text | |
dc.subject.keywords | lipid multilayers | |
dc.subject.keywords | phase separation | |
dc.subject.keywords | aligned domains | |
dc.subject.keywords | energetic considerations | |
dc.subject.keywords | lipid rafts | |