dc.contributor.author | Cabezas-Cruz, Alejandro | |
dc.contributor.author | Mateos-Hernandez, Lourdes | |
dc.contributor.author | Alberdi, Pilar | |
dc.contributor.author | Villar, Margarita | |
dc.contributor.author | Riveau, Gilles | |
dc.contributor.author | Hermann, Emmanuel | |
dc.contributor.author | Schacht, Anne-Marie | |
dc.contributor.author | Khalife, Jamal | |
dc.contributor.author | Correia-Neves, Margarida | |
dc.contributor.author | Gortazar, Christian | |
dc.contributor.author | de la Fuente, Jose | |
dc.date.accessioned | 2019-08-28T16:00:57Z | |
dc.date.available | 2019-08-28T16:00:57Z | |
dc.date.issued | 2017-03-10 | |
dc.identifier | oksd_cabezascruz_effectofbloodty_2017 | |
dc.identifier.citation | Cabezas-Cruz, A., Mateos-Hernandez, L., Alberdi, P., Villar, M., Riveau, G., Hermann, E., ... de la Fuente, J. (2017). Effect of blood type on anti-a-Gal immunity and the incidence of infectious diseases. Experimental and Molecular Medicine, 49, Article e301. https://doi.org/10.1038/emm.2016.164 | |
dc.identifier.uri | https://hdl.handle.net/11244/321394 | |
dc.description.abstract | The identification of factors affecting the susceptibility to infectious diseases is essential toward reducing their burden on the human population. The ABO blood type correlates with susceptibility to malaria and other infectious diseases. Due to the structural similarity between blood antigen B and Gala1-3GalB1-(3)4GlcNAc-R (a-Gal), we hypothesized that self-tolerance to antigen B affects the immune response to a-Gal, which in turn affects the susceptibility to infectious diseases caused by pathogens carrying a-Gal on their surface. Here we found that the incidence of malaria and tuberculosis, caused by pathogens with a-Gal on their surface, positively correlates with the frequency of blood type B in endemic regions. However, the incidence of dengue fever, caused by a pathogen without a-Gal, was not related to the frequency of blood type B in these populations. Furthermore, the incidence of malaria and tuberculosis was negatively correlated with the anti-a-Gal antibody protective response. These results have implications for disease control and prevention. | |
dc.format | application/pdf | |
dc.language | en_US | |
dc.publisher | Nature Publishing Group | |
dc.rights | This material has been previously published. In the Oklahoma State University Library's institutional repository this version is made available through the open access principles and the terms of agreement/consent between the author(s) and the publisher. The permission policy on the use, reproduction or distribution of the material falls under fair use for educational, scholarship, and research purposes. Contact Digital Resources and Discovery Services at lib-dls@okstate.edu or 405-744-9161 for further information. | |
dc.title | Effect of blood type on anti-a-Gal immunity and the incidence of infectious diseases | |
osu.filename | oksd_cabezascruz_effectofbloodty_2017.pdf | |
dc.description.peerreview | Peer reviewed | |
dc.identifier.doi | 10.1038/emm.2016.164 | |
dc.description.department | Veterinary Pathobiology | |
dc.type.genre | Article | |
dc.type.material | Text | |
dc.subject.keywords | abo blood-group system | |
dc.subject.keywords | antigens, tumor-associated, carbohydrate | |
dc.subject.keywords | humans | |
dc.subject.keywords | malaria | |
dc.subject.keywords | tuberculosis | |
dc.subject.keywords | abo blood-group system | |
dc.subject.keywords | antigens, tumor-associated, carbohydrate | |
dc.subject.keywords | sialosyl-tn antigen | |