dc.contributor.author | Moorthy, Anandi Narayana | |
dc.contributor.author | Tan, Kong Bing | |
dc.contributor.author | Wang, Shi | |
dc.contributor.author | Narasaraju, Teluguakula | |
dc.contributor.author | Chow, Vincent T. | |
dc.date.accessioned | 2019-08-28T16:00:49Z | |
dc.date.available | 2019-08-28T16:00:49Z | |
dc.date.issued | 2016-08-02 | |
dc.identifier | oksd_moorthy_effectofhigh-fa_2016 | |
dc.identifier.citation | Moorthy, A. N., Tan, K. B., Wang, S., Narasaraju, T., & Chow, V. T. (2016). Effect of high-fat diet on the formation of pulmonary neutrophil extracellular traps during influenza pneumonia in BALB/c mice. Frontiers in Immunology, 7, Article 289. https://doi.org/10.3389/fimmu.2016.00289 | |
dc.identifier.uri | https://hdl.handle.net/11244/321375 | |
dc.description.abstract | Obesity is an independent risk factor for severe outcome of influenza infection. Higher dietary fat consumption has been linked to greater morbidity and severe influenza in mouse models. However, the extent of generation of neutrophil extracellular traps (NETs or NETosis) in obese individuals during influenza pneumonia is hitherto unknown. This study investigated pulmonary NETs generation in BALB/c mice fed with high-fat diet (HFD) and low-fat diet (LFD), during the course of influenza pneumonia. Clinical disease progression, histopathology, lung reactive oxygen species, and myeloperoxidase activity were also compared. Consumption of HFD over 18 weeks led to significantly higher body weight, body mass index, and adiposity in BALB/c mice compared with LFD. Lethal challenge of mice (on HFD and LFD) with influenza A/PR/8/34 (H1N1) virus led to similar body weight loss and histopathologic severity. However, NETs were formed at relatively higher levels in mice fed with HFD, despite the absence of significant difference in disease progression between HFD- and LFD-fed mice. | |
dc.format | application/pdf | |
dc.language | en_US | |
dc.publisher | Frontiers Media | |
dc.rights | This material has been previously published. In the Oklahoma State University Library's institutional repository this version is made available through the open access principles and the terms of agreement/consent between the author(s) and the publisher. The permission policy on the use, reproduction or distribution of the material falls under fair use for educational, scholarship, and research purposes. Contact Digital Resources and Discovery Services at lib-dls@okstate.edu or 405-744-9161 for further information. | |
dc.title | Effect of high-fat diet on the formation of pulmonary neutrophil extracellular traps during influenza pneumonia in BALB/c mice | |
osu.filename | oksd_moorthy_effectofhigh-fa_2016.pdf | |
dc.description.peerreview | Peer reviewed | |
dc.identifier.doi | 10.3389/fimmu.2016.00289 | |
dc.description.department | Veterinary Health Sciences | |
dc.type.genre | Article | |
dc.type.material | Text | |
dc.subject.keywords | nets | |
dc.subject.keywords | high-fat diet | |
dc.subject.keywords | influenza | |
dc.subject.keywords | neutrophils | |
dc.subject.keywords | pneumonia | |