dc.contributor.author | de la Fuente, Jose | |
dc.contributor.author | Antunes, Sandra | |
dc.contributor.author | Bonnet, Sarah | |
dc.contributor.author | Cabezas-Cruz, Alejandro | |
dc.contributor.author | Domingos, Ana G. | |
dc.contributor.author | Estrada-Pena, Agustin | |
dc.contributor.author | Johnson, Nicholas | |
dc.contributor.author | Kocan, Katherine M. | |
dc.contributor.author | Mansfield, Karen L. | |
dc.contributor.author | Nijhof, Ard M. | |
dc.contributor.author | Papa, Anna | |
dc.contributor.author | Rudenko, Nataliia | |
dc.contributor.author | Villar, Margarita | |
dc.contributor.author | Alberdi, Pilar | |
dc.contributor.author | Torina, Alessandra | |
dc.contributor.author | Ayllon, Nieves | |
dc.contributor.author | Vancova, Marie | |
dc.contributor.author | Golovchenko, Maryna | |
dc.contributor.author | Grubhoffer, Libor | |
dc.contributor.author | Caracappa, Santo | |
dc.contributor.author | Fooks, Anthony R. | |
dc.contributor.author | Gortazar, Christian | |
dc.contributor.author | Rego, Ryan O. M. | |
dc.date.accessioned | 2019-08-28T16:00:41Z | |
dc.date.available | 2019-08-28T16:00:41Z | |
dc.date.issued | 2017-04-07 | |
dc.identifier | oksd_delafuente_tick-pathogenin_2017 | |
dc.identifier.citation | de la Fuente, J., Antunes, S., Bonnet, S., Cabezas-Cruz, A., Domingos, A. G., Estrada-Pena, A., ... Rego, R. O. M. (2017). Tick-pathogen interactions and vector competence: Identification of molecular drivers for tick-borne diseases. Frontiers in Cellular and Infection Microbiology, 7, Article 114. https://doi.org/10.3389/fcimb.2017.00114 | |
dc.identifier.uri | https://hdl.handle.net/11244/321355 | |
dc.description.abstract | Ticks and the pathogens they transmit constitute a growing burden for human and animal health worldwide. Vector competence is a component of vectorial capacity and depends on genetic determinants affecting the ability of a vector to transmit a pathogen. These determinants affect traits such as tick-host-pathogen and susceptibility to pathogen infection. Therefore, the elucidation of the mechanisms involved in tick-pathogen interactions that affect vector competence is essential for the identification of molecular drivers for tick-borne diseases. In this review, we provide a comprehensive overview of tick-pathogen molecular interactions for bacteria, viruses, and protozoa affecting human and animal health. Additionally, the impact of tick microbiome on these interactions was considered. Results show that different pathogens evolved similar strategies such as manipulation of the immune response to infect vectors and facilitate multiplication and transmission. Furthermore, some of these strategies may be used by pathogens to infect both tick and mammalian hosts. Identification of interactions that promote tick survival, spread, and pathogen transmission provides the opportunity to disrupt these interactions and lead to a reduction in tick burden and the prevalence of tick-borne diseases. Targeting some of the similar mechanisms used by the pathogens for infection and transmission by ticks may assist in development of preventative strategies against multiple tick-borne diseases. | |
dc.format | application/pdf | |
dc.language | en_US | |
dc.publisher | Frontiers Media | |
dc.rights | This material has been previously published. In the Oklahoma State University Library's institutional repository this version is made available through the open access principles and the terms of agreement/consent between the author(s) and the publisher. The permission policy on the use, reproduction or distribution of the material falls under fair use for educational, scholarship, and research purposes. Contact Digital Resources and Discovery Services at lib-dls@okstate.edu or 405-744-9161 for further information. | |
dc.title | Tick-pathogen interactions and vector competence: Identification of molecular drivers for tick-borne diseases | |
osu.filename | oksd_delafuente_tick-pathogenin_2017.pdf | |
dc.description.peerreview | Peer reviewed | |
dc.identifier.doi | 10.3389/fcimb.2017.00114 | |
dc.description.department | Veterinary Pathobiology | |
dc.type.genre | Article | |
dc.type.material | Text | |
dc.subject.keywords | anaplasma | |
dc.subject.keywords | babesia | |
dc.subject.keywords | borrelia | |
dc.subject.keywords | flavivirus | |
dc.subject.keywords | immunology | |
dc.subject.keywords | microbiome | |
dc.subject.keywords | tick | |
dc.subject.keywords | vaccine | |