dc.contributor.author | Gortazar, Christian | |
dc.contributor.author | Beltran-Beck, Beatriz | |
dc.contributor.author | Garrido, Joseba M. | |
dc.contributor.author | Aranaz, Alicia | |
dc.contributor.author | Sevilla, Iker A. | |
dc.contributor.author | Boadella, Mariana | |
dc.contributor.author | Lyashchenko, Konstantin P. | |
dc.contributor.author | Scimeca, Ruth C. | |
dc.contributor.author | Montoro, Vidal | |
dc.contributor.author | Dominguez, Lucas | |
dc.contributor.author | Juste, Ramon | |
dc.contributor.author | Fuente, Jose de la | |
dc.date.accessioned | 2019-08-21T22:01:20Z | |
dc.date.available | 2019-08-21T22:01:20Z | |
dc.date.issued | 2014-04-26 | |
dc.identifier | oksd_gortazar_oralre-vaccinat_2014 | |
dc.identifier.citation | Gortazar, C., Beltr�n-Beck, B., Garrido, J. M., Aranaz, A., Sevilla, I. A., Boadella, M., Lyashchenko, K. P., Galindo, R. C., Montoro, V., Dom�nguez, L., Juste, R., & Fuente, J. d. l. (2014). Oral re-vaccination of Eurasian wild boar with Mycobacterium bovis BCG yields a strong protective response against challenge with a field strain. BMC Veterinary Research, 10(1). https://doi.org/10.1186/1746-6148-10-96 | |
dc.identifier.uri | https://hdl.handle.net/11244/321180 | |
dc.description.abstract | Background: Field vaccination trials with Mycobacterium bovis BCG, an attenuated mutant of M. bovis, are ongoing in Spain, where the Eurasian wild boar (Sus scrofa) is regarded as the main driver of animal tuberculosis (TB). The oral baiting strategy consists in deploying vaccine baits twice each summer, in order to gain access to a high proportion of wild boar piglets. The aim of this study was to assess the response of wild boar to re-vaccination with BCG and to subsequent challenge with an M. bovis field strain. | |
dc.description.abstract | Results: BCG re-vaccinated wild boar showed reductions of 75.8% in lesion score and 66.9% in culture score, as compared to unvaccinated controls. Only one of nine vaccinated wild boar had a culture-confirmed lung infection, as compared to seven of eight controls. Serum antibody levels were highly variable and did not differ significantly between BCG re-vaccinated wild boar and controls. Gamma IFN levels differed significantly between BCG re-vaccinated wild boar and controls. The mRNA levels for IL-1b, C3 and MUT were significantly higher in vaccinated wild boar when compared to controls after vaccination and decreased after mycobacterial challenge. | |
dc.description.abstract | Conclusions: Oral re-vaccination of wild boar with BCG yields a strong protective response against challenge with a field strain. Moreover, re-vaccination of wild boar with BCG is not counterproductive. These findings are relevant given that re-vaccination is likely to happen under real (field) conditions. | |
dc.format | application/pdf | |
dc.language | en_US | |
dc.publisher | BioMed Central | |
dc.rights | This material has been previously published. In the Oklahoma State University Library's institutional repository this version is made available through the open access principles and the terms of agreement/consent between the author(s) and the publisher. The permission policy on the use, reproduction or distribution of the material falls under fair use for educational, scholarship, and research purposes. Contact Digital Resources and Discovery Services at lib-dls@okstate.edu or 405-744-9161 for further information. | |
dc.title | Oral re-vaccination of Eurasian wild boar with Mycobacterium bovis BCG yields a strong protective response against challenge with a field strain | |
osu.filename | oksd_gortazar_oralre-vaccinat_2014.pdf | |
dc.description.peerreview | Peer reviewed | |
dc.identifier.doi | 10.1186/1746-6148-10-96 | |
dc.description.department | Veterinary Pathobiology | |
dc.type.genre | Article | |
dc.type.material | Text | |
dc.subject.keywords | adaptive immunity | |
dc.subject.keywords | administration, oral | |
dc.subject.keywords | animals | |
dc.subject.keywords | bcg vaccine | |
dc.subject.keywords | gene expression regulation | |
dc.subject.keywords | immunity, innate | |
dc.subject.keywords | mycobacterium bovis | |
dc.subject.keywords | spain | |
dc.subject.keywords | sus scrofa | |
dc.subject.keywords | tuberculosis | |
dc.subject.keywords | vaccination | |
dc.subject.keywords | bcg vaccine | |