dc.contributor.advisor | Johnson, William L. | |
dc.contributor.advisor | Gustafson, John E. | |
dc.contributor.author | Fritch, Bradley R. | |
dc.contributor.author | Lanier, Braden M. | |
dc.contributor.other | HHMI Life Science Freshman Research Scholars | |
dc.date.accessioned | 2019-07-22T17:02:55Z | |
dc.date.available | 2019-07-22T17:02:55Z | |
dc.date.issued | 2019-04-27 | |
dc.identifier | oksd_hhmi_2019_fritch | |
dc.identifier | oksd_hhmi_2019_fritch_poster | |
dc.identifier.citation | Fritch, B. R., Lanier, B. M., Johnson, W. L., & Gustafson, J. E. (2019, April 27). The effects of vancomycin and ceftazidime on biofilm formation in Elizabethkingia. Paper presented at the HHMI Life Science Freshman Research Scholars Symposium, Stillwater, OK. | |
dc.identifier.uri | https://hdl.handle.net/11244/321037 | |
dc.description.abstract | Elizabethkingia infections are associated with high mortality rates which is due in part to the antibiotic resistance expressed by all Gram-negative Elizabethkingia species. Biofilm formation by Elizabethkingia provides the bacteria with further defense against the action of antibiotics. Vancomycin is an unusual drug used to treat Elizabethkingia infections, but its use is controversial, since it is normally only used to treat Gram-positive infections. Our study tests the effect of vancomycin and ceftazidime on biofilm formation for all known species of Elizabethkingia. Biofilm formation was measured at 24, 48, and 72-hour timepoints using a crystal violet biofilm assay. Biofilm formation occurred in all positive control wells for all three timepoints for all species. The biofilms of Elizabethkingia meningoseptica in the presence of subinhibitory vancomycin concentrations, and Elizabethkingia ursingii in the presence of inhibitory ceftazidime concentrations, were reduced compared to the controls. This suggests that both drugs can inhibit biofilm formation in a species-specific manner. | |
dc.description.sponsorship | Howard Hughes Medical Institute Science Education Program | |
dc.format | application/pdf | |
dc.language | en_US | |
dc.publisher | Oklahoma State University | |
dc.rights | In the Oklahoma State University Library's institutional repository this paper is made available through the open access principles and the terms of agreement/consent between the author(s) and the publisher. The permission policy on the use, reproduction or distribution of the article falls under fair use for educational, scholarship, and research purposes. Contact Digital Resources and Discovery Services at lib-dls@okstate.edu or 405-744-9161 for further information. | |
dc.title | Effects of vancomycin and ceftazidime on biofilm formation in Elizabethkingia | |
osu.filename | oksd_hhmi_2019_fritch.pdf | |
osu.filename | oksd_hhmi_2019_fritch_poster.pdf | |
dc.description.department | Biochemistry and Molecular Biology | |
dc.type.genre | Research report | |
dc.type.genre | Presentation | |
dc.type.material | Text | |
dc.subject.keywords | elizabethkingia | |
dc.subject.keywords | vancomycin | |
dc.subject.keywords | ceftazidime | |
dc.subject.keywords | biofilm formation | |
dc.subject.keywords | minimum inhibitory concentration (mic) | |