dc.contributor.advisor | Hartson, Steven D. | |
dc.contributor.author | Wagner, Lori | |
dc.contributor.author | Cartmell, Taylor | |
dc.contributor.author | Jurczak, Joanna | |
dc.contributor.author | Kiel, Klaudia | |
dc.contributor.other | HHMI Life Science Freshman Research Scholars | |
dc.date.accessioned | 2019-07-22T17:02:53Z | |
dc.date.available | 2019-07-22T17:02:53Z | |
dc.date.issued | 2019-04-27 | |
dc.identifier | oksd_hhmi_2019_WagnerCartmell | |
dc.identifier | oksd_hhmi_2019_WagnerCartmell_poster | |
dc.identifier.citation | Wagner, L., Cartmell, T., Jurczak, J., Kiel, K., & Hartson, S. D. (2019, April 27). Client depletion assay comparison of paclitaxel to Hsp90 inhibitors. Paper presented at the HHMI Life Science Freshman Research Scholars Symposium, Stillwater, OK. | |
dc.identifier.uri | https://hdl.handle.net/11244/321032 | |
dc.description.abstract | Many researchers have claimed they have found a successful inhibitor of Hsp90; however, we suspect they are only successful when the inhibitor is used in large quantities. On top of being one of the easiest ways to show an effective inhibitor, researchers are claiming they have found an inhibitor when only meeting as few as two hallmarks. Due to the researchers' inhibitors only meeting two of the criteria, we are trying to show whether these limited expectations are a valid way in identifying Hsp90 inhibitors. We think the client depletion assay test is not specific to Hsp90 inhibitors but instead is a generalized cell response to cell death. At this point in our research, we know a lot about client depletion assays and Hsp90s; however, we do not know if the claims these researchers are making are valid claims because of the amount of Hsp90 inhibitor they are using. | |
dc.description.sponsorship | Howard Hughes Medical Institute Science Education Program | |
dc.format | application/pdf | |
dc.language | en_US | |
dc.publisher | Oklahoma State University | |
dc.rights | In the Oklahoma State University Library's institutional repository this paper is made available through the open access principles and the terms of agreement/consent between the author(s) and the publisher. The permission policy on the use, reproduction or distribution of the article falls under fair use for educational, scholarship, and research purposes. Contact Digital Resources and Discovery Services at lib-dls@okstate.edu or 405-744-9161 for further information. | |
dc.title | Client depletion assay comparison of paclitaxel to Hsp90 inhibitors | |
osu.filename | oksd_hhmi_2019_WagnerCartmell.pdf | |
osu.filename | oksd_hhmi_2019_WagnerCartmell_poster.pdf | |
dc.description.department | Biochemistry and Molecular Biology | |
dc.type.genre | Research report | |
dc.type.genre | Presentation | |
dc.type.material | Text | |
dc.subject.keywords | hsp90s | |
dc.subject.keywords | client depletion assay | |
dc.subject.keywords | apoptosis | |
dc.subject.keywords | inhibitors | |