Single step polyfluoroarylation of amides
Date
2019-04-27Author
Noel, Alyssa
Hamilton, Matthew
Jesperson, Daniel
Keen, Brockton
Metadata
Show full item recordAbstract
Per- and polyfluoroarenes are important synthetic chemistry targets because they are active components in many pharmaceuticals, agrichemicals, and industrial manufacturing products. Many of the current methods of synthesizing these fluoroarenes involves selectively adding fluorines one at a time. These procedures are rudimentary and often demand long and harsh reaction conditions and often result in poor yields. Novel substrates can be reached, however, through selective hydrodefluorination or functionalization, i.e. fluorine sculpting. This research compliments recently developed chemistry which synthesizes starting material fluoroarenes in two steps by shortening the synthesis by 50%. This chemistry utilizes nucleophilic aromatic substitution to synthesize per- and poly-fluoroaryl amides in a single step under mild reaction conditions which can then be utilized for fluorine sculpting.
Citation
Noel, A., Hamilton, M., Jesperson, D., Keen, B., Day, J., & Weaver, J. D. (2019, April 27). A single step polyfluoroarylation of amides. Paper presented at the HHMI Life Science Freshman Research Scholars Symposium, Stillwater, OK.