Currently, non-communicable diseases (NCDs) such as cardiovascular diseases, cancers, diabetes and chronic respiratory diseases are a primary threat to human health and development. International and domestic health organizations have called attention to this emerging health care crisis within the United States. This research suggests a systemic, message-based inoculation strategy presents empirically demonstrable techniques useful in stemming the rising rates of NCDs in the U.S. population, by helping to confer a more healthy resistance to puffed up health and nutrition related (HNR) advertising content claims. This research advances inoculation theory by bolstering the force of refutational preemption through good regulatory fit (Higgins, 1997; 1998).