| dc.contributor.author | Wang, Pengcheng | |
| dc.contributor.author | Chintagari, Narendranath Reddy | |
| dc.contributor.author | Narayanaperumal, Jeyaparthasarathy | |
| dc.contributor.author | Ayalew, Sahlu | |
| dc.contributor.author | Hartson, Steven | |
| dc.contributor.author | Liu, Lin | |
| dc.date.accessioned | 2018-11-09T21:11:00Z | |
| dc.date.available | 2018-11-09T21:11:00Z | |
| dc.date.issued | 2008-06-24 | |
| dc.identifier | oksd_wang_proteomicanalys_2008 | |
| dc.identifier.citation | Wang, P., Chintagari, N. R., Narayanaperumal, J., Ayalew, S., Hartson, S., & Liu, L. (2008). Proteomic analysis of lamellar bodies isolated from rat lungs. BMC Cell Biology, 9, Article 34. https://doi.org/10.1186/1471-2121-9-34 | |
| dc.identifier.uri | https://hdl.handle.net/11244/302080 | |
| dc.description.abstract | Background: Lamellar bodies are lysosome-related secretory granules and store lung surfactant in alveolar type II cells. To better understand the mechanisms of surfactant secretion, we carried out proteomic analyses of lamellar bodies isolated from rat lungs. | |
| dc.description.abstract | Results: With peptide mass fingerprinting by Matrix Assisted Laser Desorption/Ionization - Time of Flight mass spectrometry, 44 proteins were identified with high confidence. These proteins fell into diverse functional categories: surfactant-related, membrane trafficking, calcium binding, signal transduction, cell structure, ion channels, protein processing and miscellaneous. Selected proteins were verified by Western blot and immunohistochemistry. | |
| dc.description.abstract | Conclusion: This proteomic profiling of lamellar bodies provides a basis for further investigations of functional roles of the identified proteins in lamellar body biogenesis and surfactant secretion. | |
| dc.format | application/pdf | |
| dc.language | en_US | |
| dc.publisher | BioMed Central | |
| dc.rights | This material has been previously published. In the Oklahoma State University Library's institutional repository this version is made available through the open access principles and the terms of agreement/consent between the author(s) and the publisher. The permission policy on the use, reproduction or distribution of the material falls under fair use for educational, scholarship, and research purposes. Contact Digital Resources and Discovery Services at lib-dls@okstate.edu or 405-744-9161 for further information. | |
| dc.title | Proteomic analysis of lamellar bodies isolated from rat lungs | |
| osu.filename | oksd_wang_proteomicanalys_2008.pdf | |
| dc.description.peerreview | Peer reviewed | |
| dc.identifier.doi | 10.1186/1471-2121-9-34 | |
| dc.description.department | Physiological Sciences | |
| dc.description.department | Veterinary Pathobiology | |
| dc.description.department | Biochemistry and Molecular Biology | |
| dc.type.genre | Article | |
| dc.type.material | Text | |
| dc.subject.keywords | DPPC | |
| dc.subject.keywords | alveolar type | |
| dc.subject.keywords | lamellar body | |
| dc.subject.keywords | lung surfactant | |
| dc.subject.keywords | surfactant secretion | |
