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Identification of rat lung-specific microRNAs by micoRNA microarray: Valuable discoveries for the facilitation of lung research

dc.contributor.authorWang, Yang
dc.contributor.authorWeng, Tingting
dc.contributor.authorGou, Deming
dc.contributor.authorChen, Zhongming
dc.contributor.authorChintagari, Narendranath Reddy
dc.contributor.authorLiu, Lin
dc.date.accessioned2018-11-09T21:10:59Z
dc.date.available2018-11-09T21:10:59Z
dc.date.issued2007-01-24
dc.identifieroksd_wang_identificationo_2007
dc.identifier.citationWang, Y., Weng, T., Gou, D., Chen, Z., Chintagari, N. R., & Liu, L. (2007). Identification of rat lung-specific microRNAs by micoRNA microarray: Valuable discoveries for the facilitation of lung research. BMC Genomics, 8, Article 29. https://doi.org/10.1186/1471-2164-8-29
dc.identifier.urihttps://hdl.handle.net/11244/302079
dc.description.abstractBackground: An important mechanism for gene regulation utilizes small non-coding RNAs called microRNAs (miRNAs). These small RNAs play important roles in tissue development, cell differentiation and proliferation, lipid and fat metabolism, stem cells, exocytosis, diseases and cancers. To date, relatively little is known about functions of miRNAs in the lung except lung cancer.
dc.description.abstractResults: In this study, we utilized a rat miRNA microarray containing 216 miRNA probes, printed in-house, to detect the expression of miRNAs in the rat lung compared to the rat heart, brain, liver, kidney and spleen. Statistical analysis using Significant Analysis of Microarray (SAM) and Tukey Honestly Significant Difference (HSD) revealed 2 miRNAs (miR-195 and miR-200c) expressed specifically in the lung and 9 miRNAs co-expressed in the lung and another organ. 12 selected miRNAs were verified by Northern blot analysis.
dc.description.abstractConclusion: The identified lung-specific miRNAs from this work will facilitate functional studies of miRNAs during normal physiological and pathophysiological processes of the lung.
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dc.languageen_US
dc.publisherBioMed Central
dc.rightsThis material has been previously published. In the Oklahoma State University Library's institutional repository this version is made available through the open access principles and the terms of agreement/consent between the author(s) and the publisher. The permission policy on the use, reproduction or distribution of the material falls under fair use for educational, scholarship, and research purposes. Contact Digital Resources and Discovery Services at lib-dls@okstate.edu or 405-744-9161 for further information.
dc.titleIdentification of rat lung-specific microRNAs by micoRNA microarray: Valuable discoveries for the facilitation of lung research
osu.filenameoksd_wang_identificationo_2007.pdf
dc.description.peerreviewPeer reviewed
dc.identifier.doi10.1186/1471-2164-8-29
dc.description.departmentPhysiological Sciences
dc.type.genreArticle
dc.type.materialText
dc.subject.keywordsnorthern blot
dc.subject.keywordshonestly significant difference
dc.subject.keywordscommon reference
dc.subject.keywordsserum response factor
dc.subject.keywordsmiRNA microarray


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