dc.contributor.author | Posey, Tisha | |
dc.contributor.author | Weng, Tingting | |
dc.contributor.author | Chen, Zhongming | |
dc.contributor.author | Chintagari, Narendranath R. | |
dc.contributor.author | Wang, Pengcheng | |
dc.contributor.author | Jin, Nili | |
dc.contributor.author | Stricker, Heidi | |
dc.contributor.author | Liu, Lin | |
dc.date.accessioned | 2018-11-09T21:10:50Z | |
dc.date.available | 2018-11-09T21:10:50Z | |
dc.date.issued | 2008-03-03 | |
dc.identifier | oksd_posey_arsenic-induced_2008 | |
dc.identifier.citation | Posey, T., Weng, T., Chen, Z., Chintagari, N. R., Wang, P., Jin, N., ... Liu, L. (2008). Arsenic-induced changes in the gene expression of lung epithelial L2 cells: Implications in carcinogenesis. BMC Genomics, 9, Article 115. https://doi.org/10.1186/1471-2164-9-115 | |
dc.identifier.uri | https://hdl.handle.net/11244/302062 | |
dc.description.abstract | Background: Arsenic is a carcinogen that is known to induce cell transformation and tumor formation. Although studies have been performed to examine the modulation of signaling molecules caused by arsenic exposure, the molecular mechanisms by which arsenic causes cancer are still unclear. We hypothesized that arsenic alters gene expression leading to carcinogenesis in the lung. | |
dc.description.abstract | Results: In this study, we examined global gene expression in response to 0.75 uM arsenic treatment for 1 - 7 days in a rat lung epithelial cell line (L2) using an in-house 10 k rat DNA microarray. One hundred thirty one genes were identified using the one-class statistical analysis of microarray (SAM) test. Of them, 33 genes had a fold change of >/= 2 between at least two time points. These genes were then clustered into 5 groups using K-means cluster analysis based on their expression patterns. Seven selected genes, all associated with cancer, were confirmed by real-time PCR. These genes have functions directly or indirectly related to metabolism, glycolysis, cell proliferation and differentiation, and regulation of transcription. | |
dc.description.abstract | Conclusion: Our findings provide important insight for the future studies of arsenic-mediated lung cancer. | |
dc.format | application/pdf | |
dc.language | en_US | |
dc.publisher | BioMed Central | |
dc.rights | This material has been previously published. In the Oklahoma State University Library's institutional repository this version is made available through the open access principles and the terms of agreement/consent between the author(s) and the publisher. The permission policy on the use, reproduction or distribution of the material falls under fair use for educational, scholarship, and research purposes. Contact Digital Resources and Discovery Services at lib-dls@okstate.edu or 405-744-9161 for further information. | |
dc.title | Arsenic-induced changes in the gene expression of lung epithelial L2 cells: Implications in carcinogenesis | |
osu.filename | oksd_posey_arsenic-induced_2008.pdf | |
dc.description.peerreview | Peer reviewed | |
dc.identifier.doi | 10.1186/1471-2164-9-115 | |
dc.description.department | Physiological Sciences | |
dc.type.genre | Article | |
dc.type.material | Text | |
dc.subject.keywords | arsenic | |
dc.subject.keywords | arsenite | |
dc.subject.keywords | arsenic exposure | |
dc.subject.keywords | sodium arsenite | |
dc.subject.keywords | triosephosphate isomerase | |