In the first half of the 17th century, Dutch astronomers rapidly abandoned the practice of astrology. By the second half of the century, no trace of it was left in Dutch academic discourse. This abandonment, in its early stages, does not appear as the result of criticism or skepticism, although such skepticism was certainly known in the Dutch Republic and leading humanist scholars referred to Pico’s arguments against astrological predictions. The astronomers, however, did not really refute astrology, but simply stopped paying attention to it, as other questions (in particular the constitution of the universe) became the focus of their scholarship. The underlying physical view of the world, with its idea of celestial influences, remained in vigor much longer. Even convinced anti-Aristotelians, in explaining the world, tried to account for the effects of the oppositions and conjunctions of planets, and similar elements. It is only with Descartes that the by now widespread skepticism about predictions found expression in a philosophy that denied celestial influence.