dc.contributor.author | Sebastien A. Gauthier | |
dc.contributor.author | Eric VanHaaften | |
dc.contributor.author | Lucy Cherbas | |
dc.contributor.author | Peter Cherbas | |
dc.contributor.author | Randall S. Hewes | |
dc.date.accessioned | 2016-01-08T19:47:47Z | |
dc.date.accessioned | 2016-03-30T15:32:57Z | |
dc.date.available | 2016-01-08T19:47:47Z | |
dc.date.available | 2016-03-30T15:32:57Z | |
dc.date.issued | 2012-08-09 | |
dc.identifier.citation | Gauthier SA, VanHaaften E, Cherbas L, Cherbas P, Hewes RS (2012) Cryptocephal, the Drosophila melanogaster ATF4, Is a Specific Coactivator for Ecdysone Receptor Isoform B2. PLoS Genetics 8(8): e1002883. doi:10.1371/journal.pgen.1002883 | en_US |
dc.identifier.uri | https://hdl.handle.net/11244/23532 | |
dc.description | We thank Yoonseung Park (Kansas State University) and Michael Adams (UC Riverside) for the ETH-GeneSwitch line, and David Durica, Lauren Evans, and Dahong Chen (University of Oklahoma) and Nancy Thompson (Indiana University) for technical assistance. | en_US |
dc.description | | en_US |
dc.description.abstract | Author Summary Nuclear receptors are proteins that regulate gene expression in response to steroid and thyroid hormones and other small lipid-soluble signaling molecules. In many cases, nuclear receptor genes encode multiple variants (isoforms) that direct tissue- and stage-specific hormonal responses. The sequence differences among isoforms are often found at the protein N-terminus, which mediates hormone-independent interactions with unknown regulatory partners to control target gene expression. Here, we show that the fruit fly Cryptocephal (CRC) protein is a specific coactivator for one of three isoforms of the receptor for the insect molting steroid, ecdysone. Our findings reveal a mechanism for differential activation of gene expression in response to ecdysone during insect molting and metamorphosis, and contribute to our understanding of isoform-specific functions of nuclear hormone receptors. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | PLos Genetics | |
dc.relation.ispartofseries | PLoS Genetics 8(8):e1002883 | |
dc.relation.uri | http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1002883 | |
dc.rights | Attribution 3.0 United States | |
dc.rights.uri | https://creativecommons.org/licenses/by/3.0/us/ | |
dc.subject | Larvae,Molting,Basic leucine zipper domain,DNA-binding proteins,Drosophila melanogaster,Gene expression,DNA transcription,Transcription factors | en_US |
dc.title | Cryptocephal, the Drosophila melanogaster ATF4, Is a Specific Coactivator for Ecdysone Receptor Isoform B2 | en_US |
dc.type | Research Article | en_US |
dc.description.peerreview | Yes | en_US |
dc.description.peerreviewnotes | http://www.plosgenetics.org/static/editorial#peer | en_US |
dc.identifier.doi | 10.1371/journal.pgen.1002883 | en_US |
dc.rights.requestable | false | en_US |