| dc.contributor.author | Benbrook, Doris M. | |
| dc.contributor.author | Miller, Robert V. | |
| dc.date.accessioned | 2015-10-16T20:48:31Z | |
| dc.date.available | 2015-10-16T20:48:31Z | |
| dc.date.issued | 1986-01 | |
| dc.identifier | okds_Miller_AMAC_1986-01.pdf | |
| dc.identifier.citation | Benbrook, D. M., & Miller, R. V. (1986). Effects of norfloxacin on DNA metabolism in Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy, 29(1), 1-6. https://doi.org/10.1128/AAC.29.1.1 | |
| dc.identifier.uri | https://hdl.handle.net/11244/19931 | |
| dc.description.abstract | Norfloxacin is a quinolone (pyridonecarboxylic acid derivative) effective against Pseudomonas aeruginosa infections. We studied the effects of this drug on DNA metabolism in P. aeruginosa. Norfloxacin inhibits DNA replication immediately on its addition to a logarithmically growing culture of P. aeruginosa. It inhibits the ability of P. aeruginosa DNA gyrase to supercoil relaxed, closed circular DNA in vitro. At intermediate concentrations of the drug, inhibition of DNA replication in vivo is followed by secondary (recovery) synthesis. Both recovery synthesis and the bactericidal effects of norfloxacin are dependent on continued protein synthesis, suggesting that these are inducible functions. Neither norfloxacin nor nalidixic acid induces Weigle-reactivation (inducible DNA repair) or mutagenesis in P. aeruginosa. | |
| dc.format | application/pdf | |
| dc.language | en_US | |
| dc.publisher | American Society for Microbiology | |
| dc.rights | This material has been previously published. In the Oklahoma State University Library's institutional repository this version is made available through the open access principles and the terms of agreement/consent between the author(s) and the publisher. The permission policy on the use, reproduction or distribution of the material falls under fair use for educational, scholarship, and research purposes. Contact Digital Resources and Discovery Services at lib-dls@okstate.edu or 405-744-9161 for further information. | |
| dc.title | Effects of norfloxacin on DNA metabolism in Pseudomonas aeruginosa | |
| osu.filename | okds_Miller_AMAC_1986-01.pdf | |
| dc.description.peerreview | Peer reviewed | |
| dc.identifier.doi | 10.1128/AAC.29.1.1 | |
| dc.description.department | Microbiology and Molecular Genetics | |
| dc.type.genre | Article | |
| dc.type.material | Text | |
