dc.contributor.author | Kocan, Katherine M. | |
dc.contributor.author | Crawford, Timothy B. | |
dc.contributor.author | Dilbeck, Pamela M. | |
dc.contributor.author | Evermann, James F. | |
dc.contributor.author | McGuire, Travis C. | |
dc.date.accessioned | 2015-10-16T20:47:59Z | |
dc.date.available | 2015-10-16T20:47:59Z | |
dc.date.issued | 1990-10 | |
dc.identifier | okds_Ford-Kocan_JB_1990-10.pdf | |
dc.identifier.citation | Kocan, K. M., Crawford, T. B., Dilbeck, P. M., Evermann, J. F., & McGuire, T. C. (1990). Development of a rickettsia isolated from an aborted bovine fetus. Journal of Bacteriology, 172(10), 5949-5955. https://doi.org/10.1128/jb.172.10.5949-5955.1990 | |
dc.identifier.uri | https://hdl.handle.net/11244/19829 | |
dc.description.abstract | An obligate intracellular rickettsial organism isolated from an aborted bovine fetus was studied in bovine turbinate and mouse macrophage cell cultures with light and electron microscopy. Development of the organism was similar in both cell types. The organism replicated within cytoplasmic vacuoles in a developmental cycle that resembled that of both the ehrlichiae and chlamydiae. The inoculum contained only electron-dense forms, which infected cells within 2 h postinoculation by adhering to cell membranes at thickened areas that appeared to be coated pits and then being endocytosed. A striking feature occurred next as the organisms became surrounded by host cell mitochondria and, by light microscopy, appeared to have halos. During this intimate association with mitochondria, the electron-dense organisms changed into large reticulated forms that began to divide by binary fission. These large forms were often in direct contact with mitochondrial membranes. The organisms continued to divide by binary fission, and host cells contained large cytoplasmic inclusions of reticulated organisms. The reticulated organisms gradually changed into electron-dense forms that were released from degenerated host cells. | |
dc.format | application/pdf | |
dc.language | en_US | |
dc.publisher | American Society for Microbiology | |
dc.rights | This material has been previously published. In the Oklahoma State University Library's institutional repository this version is made available through the open access principles and the terms of agreement/consent between the author(s) and the publisher. The permission policy on the use, reproduction or distribution of the material falls under fair use for educational, scholarship, and research purposes. Contact Digital Resources and Discovery Services at lib-dls@okstate.edu or 405-744-9161 for further information. | |
dc.title | Development of a rickettsia isolated from an aborted bovine fetus | |
osu.filename | okds_Kocan_JB_1990-10.pdf | |
dc.description.peerreview | Peer reviewed | |
dc.identifier.doi | 10.1128/jb.172.10.5949-5955.1990 | |
dc.description.department | Veterinary Pathology | |
dc.type.genre | Article | |
dc.type.material | Text | |