Next Generation Sequencing (NGS), the basis for volume sequencing enablement, has been around for several years. The volume of sequencers deployed per year remains on an exponential growth path. Nevertheless, the vision of sequencing-enabled personalized medicine has come to fruition for relatively few people. The community consensus is that bringing this to large populations remains 5-7 years out. Nevertheless, some projects are underway to path-find means to accelerate this. In this talk, we will review the solution architecture that will enable this from a technology perspective. Furthermore, we will review the efforts of the Intel/HP HPC Alliance with respect to driving these solutions into actual implementation. While the solutions architecture will be focused on the NGS work flow, the elements of the architecture are pertinent to other HPC work flows.