Little exists in the field of psychology regarding American Indian sweat purification ceremonies, and even less exists in psychological literature on the impact of gender on such ceremonies or gender from this cultural perspective as a whole. Using generic qualitative analysis this study explored the experiences of individuals who participate in American Indian sweat purification ceremonies, with specific interest in how gender impacts the experience and how the experience impacts overall well-being. The study found one primary theme (Inter-connectedness) and four sub-themes (Genderlessness, Psychological Healing, Physical Healing, and Escape) using a focus group format to interview American Indians who participated in sweat purification ceremonies.