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In vitro efficacy of new antifolates against trimethoprim-resistant Bacillus anthracis
(American Society for Microbiology, 2007-12)
Bacillus anthracis is innately resistant to trimethoprim (TMP), a synthetic antifolate that selectively inhibits several bacterial dihydrofolate reductases (DHFRs) but not human DHFR. Previously, we were able to confirm ...