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Low seroprevalence of antibodies to Toxoplasma gondii in blood donors in central Namibia
(Informa UK Limited, 2014)
Although emphasis has been placed on research relating to human immunodeficiency virus (HIV), tuberculosis and malaria, several researchers in Africa are focusing on other threats to human health, such as neglected tropical ...
Role of the Mycobacterium tuberculosis ESX-4 secretion system in heme iron utilization and pore formation by PPE proteins
(American Society for Microbiology, 2023-02-07)
Mycobacterium tuberculosis (Mtb) is transmitted through aerosols and primarily colonizes within the lung. The World Health Organization estimates that Mtb kills ~1.4 million people every year. A key aspect that makes Mtb ...
Risk assessment of flavivirus transmission in Namibia
(Elsevier BV, 2014-05-25)
The role of arboviruses causing acute febrile illness in sub-Saharan Africa is receiving more attention. Reports of dengue in tourists were published nearly 10 years ago in Namibia, but the current epidemiology of arboviruses ...
Exogenously scavenged and endogenously synthesized heme are differentially utilized by Mycobacterium tuberculosis
(American Society for Microbiology, 2022-10-26)
Heme is both an essential cofactor and an abundant source of nutritional iron for the human pathogen Mycobacterium tuberculosis. While heme is required for M. tuberculosis survival and virulence, it is also potentially ...
Quantitation of Plasmodium falciparum sporozoites transmitted in vitro by experimentally infected Anopheles gambiae and Anopheles stephensi
(American Society of Tropical Medicine and Hygiene, 1991)
The frequency and numbers of Plasmodium falciparum sporozoites transmitted in vitro and corresponding sporozoite loads were determined for experimentally infected Anopheles gambiae and An. stephensi. Geometric mean (GM) ...
Mycobacteria, metals, and the macrophage
(Wiley, 2015-03)
Mycobacterium tuberculosis is a facultative intracellular pathogen that thrives inside host macrophages. A key trait of M. tuberculosis is to exploit and manipulate metal cation trafficking inside infected macrophages to ...
Updated checklist of the mosquitoes of Oklahoma including new state records and West Nile virus vectors, 2003-06
(The American Mosquito Control Association, 2015-12)
The mosquito fauna of Oklahoma has not been evaluated since 1965 and no report has been published concerning species associated with urban areas in the state. Mosquito collections were conducted as part of the West Nile ...
Flea-borne rickettsioses: Ecologic considerations
(Centers for Disease Control and Prevention (CDC), 1997-07)
Ecologic and economic factors, as well as changes in human behavior, have resulted in the emergence of new and the reemergence of existing but forgotten infectious diseases during the past 20 years. Flea-borne disease ...
Neglected tropical diseases of Namibia: Unsolved mysteries
(Elsevier BV, 2012-09-21)
Neglected tropical diseases (NTDs) are diseases most commonly found in settings of poverty and are responsible for the morbidity and/or mortality of millions each year. As an upper-middle income country, Namibia is not ...
PPE surface proteins are required for heme utilization by Mycobacterium tuberculosis
(American Society for Microbiology, 2017-03-08)
Iron is essential for replication of Mycobacterium tuberculosis, but iron is efficiently sequestered in the human host during infection. Heme constitutes the largest iron reservoir in the human body and is utilized by many ...