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Sigma factor n, liaison to an ntrC and rpoS dependent regulatory pathway controlling acid resistance and the LEE in enterohemorrhagic Escherichia coli
(Public Library of Science (PLoS), 2012)
Enterohemorrhagic Escherichia coli (EHEC) is dependent on acid resistance for gastric passage and low oral infectious dose, and the locus of enterocyte effacement (LEE) for intestinal colonization. Mutation of rpoN, encoding ...
Role of the Mycobacterium tuberculosis ESX-4 secretion system in heme iron utilization and pore formation by PPE proteins
(American Society for Microbiology, 2023-02-07)
Mycobacterium tuberculosis (Mtb) is transmitted through aerosols and primarily colonizes within the lung. The World Health Organization estimates that Mtb kills ~1.4 million people every year. A key aspect that makes Mtb ...
Exogenously scavenged and endogenously synthesized heme are differentially utilized by Mycobacterium tuberculosis
(American Society for Microbiology, 2022-10-26)
Heme is both an essential cofactor and an abundant source of nutritional iron for the human pathogen Mycobacterium tuberculosis. While heme is required for M. tuberculosis survival and virulence, it is also potentially ...
Mycobacteria, metals, and the macrophage
(Wiley, 2015-03)
Mycobacterium tuberculosis is a facultative intracellular pathogen that thrives inside host macrophages. A key trait of M. tuberculosis is to exploit and manipulate metal cation trafficking inside infected macrophages to ...
PPE surface proteins are required for heme utilization by Mycobacterium tuberculosis
(American Society for Microbiology, 2017-03-08)
Iron is essential for replication of Mycobacterium tuberculosis, but iron is efficiently sequestered in the human host during infection. Heme constitutes the largest iron reservoir in the human body and is utilized by many ...