Browsing OSU - Faculty and Staff Publications by Author "Lacombe, Veronique A."
Now showing items 1-2 of 2
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Advanced glycation end product cross-link breaker attenuates diabetes-induced cardiac dysfunction by improving sarcoplasmic reticulum calcium handling
Kranstuber, Allyson L.; del Rio, Carlos; Biesiadecki, Brandon J.; Hamlin, Robert L.; Ottobre, Joseph; Gyorke, Sandor; Lacombe, Veronique A. (Frontiers Media, 2012-07-19)Diabetic heart disease is a distinct clinical entity that can progress to heart failure and sudden death. However, the mechanisms responsible for the alterations in excitation-contraction coupling leading to cardiac ... -
Hyperinsulinemia down-regulates TLR4 expression in the mammalian heart
de Laat, Melody A.; Gruntmeir, Kaylynn J.; Pollitt, Christopher C.; McGowan, Catherine M.; Sillence, Martin N.; Lacombe, Veronique A. (Frontiers Media, 2014-07-22)Toll-like receptors (TLR) are key regulators of innate immune and inflammatory responses and their activation is linked to impaired glucose metabolism during metabolic disease. Determination of whether TLR4 signaling can ...