Browsing OSU - Faculty and Staff Publications by Author "Deng, Junpeng"
Now showing items 1-3 of 3
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Crystallization of interleukin-18 for structure-based inhibitor design
Krumm, Brian; Meng, Xiangzhi; Xiang, Yan; Deng, Junpeng (International Union of Crystallography, 2015)Interleukin-18 (IL-18) is a pleiotropic pro-inflammatory cytokine belonging to the IL-1 superfamily. IL-18 plays an important role in host innate and acquired immune defense, with its activity being modulated in vivo by ... -
Structure of a prophenoloxidase (PPO) from Anopheles gambiae provides new insights into the mechanism of PPO activation
Hu, Yingxia; Wang, Yang; Deng, Junpeng; Jiang, Haobo (BioMed Central, 2016-01-05)Background: Phenoloxidase (PO)-catalyzed melanization is a universal defense mechanism of insects against pathogenic and parasitic infections. In mosquitos such as Anopheles gambiae, melanotic encapsulation is a resistance ... -
Structure of the unique SEFIR domain from human interleukin 17 receptor A reveals a composite ligand-binding site containing a conserved a-helix for Act1 binding and IL-17 signaling
Zhang, Bing; Liu, Caini; Qian, Wen; Han, Yue; Li, Xiaoxia; Deng, Junpeng (International Union of Crystallography, 2014)Interleukin 17 (IL-17) cytokines play a crucial role in mediating inflammatory and autoimmune diseases. A unique intracellular signaling domain termed SEFIR is found within all IL-17 receptors (IL-17Rs) as well as the key ...