Browsing OSU - Faculty and Staff Publications by Author "Barrow, William W."
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Crystal structure of Bacillus anthracis dihydrofolate reductase with the dihydrophthalazine-based trimethoprim derivative RAB1 provides a structural explanation of potency and selectivity
Bourne, Christina R.; Bunce, Richard A.; Bourne, Philip C.; Berlin, K. Darrell; Barrow, Esther W.; Barrow, William W. (American Society for Microbiology, 2009-07)Bacillus anthracis possesses an innate resistance to the antibiotic trimethoprim due to poor binding to dihydrofolate reductase (DHFR); currently, there are no commercial antibacterials that target this enzyme in B. ... -
Functional cloning of Bacillus anthracis dihydrofolate reductase and confirmation of natural resistance to trimethoprim
Barrow, Esther W.; Bourne, Philip C.; Barrow, William W. (American Society for Microbiology, 2004-12)Bacillus anthracis is reported to be naturally resistant to trimethoprim (TMP), a drug that inhibits dihydrofolate reductase (DHFR), a key enzyme in the folate pathway. A microdilution broth assay established that the MIC ... -
In vitro efficacy of new antifolates against trimethoprim-resistant Bacillus anthracis
Barrow, Esther W.; Dreier, Jurg; Reinelt, Stefan; Bourne, Philip C.; Barrow, William W. (American Society for Microbiology, 2007-12)Bacillus anthracis is innately resistant to trimethoprim (TMP), a synthetic antifolate that selectively inhibits several bacterial dihydrofolate reductases (DHFRs) but not human DHFR. Previously, we were able to confirm ...