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Sp110 transcription is induced and required by Anaplasma phagocytophilumfor infection of human promyelocytic cells
(BioMed Central, 2007-09-20)
Background: The tick-borne intracellular pathogen, Anaplasma phagocytophilum (Rickettsiales: Anaplasmataceae) causes human granulocytic anaplasmosis after infection of polymorphonuclear leucocytes. The human Sp110 gene is ...
Coxiella burnetii Nine Mile II proteins modulate gene expression of monocytic host cells during infection
(BioMed Central, 2010-09-20)
Background: Coxiella burnetii is an intracellular bacterial pathogen that causes acute and chronic disease in humans. Bacterial replication occurs within enlarged parasitophorous vacuoles (PV) of eukaryotic cells, the ...
Heme and hemoglobin utilization by Mycobacterium tuberculosis
(Springer Nature, 2019-09-18)
Iron is essential for growth of Mycobacterium tuberculosis (Mtb), but most iron in the human body is stored in heme within hemoglobin. Here, we demonstrate that the substrate-binding protein DppA of the inner membrane Dpp ...