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Functional cloning of Bacillus anthracis dihydrofolate reductase and confirmation of natural resistance to trimethoprim
(American Society for Microbiology, 2004-12)
Bacillus anthracis is reported to be naturally resistant to trimethoprim (TMP), a drug that inhibits dihydrofolate reductase (DHFR), a key enzyme in the folate pathway. A microdilution broth assay established that the MIC ...