dc.date.accessioned | 2015-07-23T15:35:49Z | |
dc.date.available | 2015-07-23T15:35:49Z | |
dc.date.issued | 2007-07-17 | |
dc.identifier | pat7244435 | |
dc.identifier.uri | https://hdl.handle.net/11244/15397 | |
dc.description.abstract | The invention is for a DNA vaccine expressing the hemagglutinin (HA1) gene of equine-2 influenza virus. By engineering a stop codon within HA1, expression of HA1 is ensured. By encapsulation of the DNA vaccine in liposome and by intranasal inoculation, it is sufficient to elicit protective immunity at a significantly lower dosage compared to a DNA vaccine expressing the full length HA gene. Lower dosage reduces the risk of induction of anti-DNA antibodies. Intranasal inoculation directly to the respiratory epithelial cells reduces the risk of DNA integration. The inventive vaccine is advantageous over current inactivated or live attenuated vaccines, as updating of the vaccine requires only the replacement of the encoding sequence with the new virus. | |
dc.format | application/pdf | |
dc.format.extent | 16 pages | |
dc.language | en_US | |
dc.publisher | U.S. Patent and Trademark Office | |
dc.title | DNA Vaccine Expressing Ha1 of Equine-2 Influenza Virus | |
dc.type | text | |
osu.filename | pat7244435.pdf | |
osu.accesstype | Open Access | |
dc.type.genre | Patent | |
dc.contributor.inventor | Lai, Alexander | |
dc.identifier.patentID | 7,244,435 | |
dc.date.filed | 2004-04-16 | |
dc.contributor.assignee | Board of Regents/Oklahoma State University and the A & M Colleges | |
dc.subject.primaryusclass | 424/210.1 | |
dc.subject.otherusclasses | 424/186.1 | |
dc.subject.otherusclasses | 435/235.1 | |
dc.subject.cpcclasses | A61K 39/145 (20130101) | |
dc.subject.cpcclasses | A61K 39/12 (20130101) | |
dc.subject.cpcclasses | C07K 14/005 (20130101) | |
dc.subject.cpcclasses | A61K 2039/53 (20130101) | |
dc.subject.cpcclasses | A61K 2039/543 (20130101) | |
dc.subject.cpcclasses | A61K 2039/552 (20130101) | |
dc.subject.cpcclasses | C12N 2760/16122 (20130101) | |
dc.subject.cpcclasses | C12N 2760/16134 (20130101) | |
dc.subject.cpcclasses | A61K 2039/55555 (20130101) | |