Heteroarotinoids Containing Urea or Thiourea Linker
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Date
2003-07-01Author
Berlin, Kenneth Darrell
Benbrook, Doris M.
Nelson, Eldon C.
Board of Regents/Oklahoma State University and the A & M Colleges
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Compounds, known as heteroarotinoids, having varying abilities to inhibit growth of certain cancerous cells, induce normal cell differentiation, and induce apoptosis or death of cancerous cells, of the general formula: ##STR1## in which: Ar and Ar' denote aryl substituents, and wherein at least one of said aryl substituents comprises an aromatic ring having at least one heteroatom in a fused, partially saturated ring; W denotes O or S; and Q denotes H or i-C.sub.3 H.sub.7.
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