Directed Determination of Cholesterol Lipid Distributions Using Circular Dichroism�

Abstract

The correlation between high cholesterol concentrations in human blood and the risk for coronary heart disease has prompted a national effort to identify and treat all American adults who are at high risk because of elevated cholesterol levels. This effort has been very successful in increasing the awareness of the public about the importance of monitoring cholesterol levels. For this awareness� to be truly beneficial requires that precise and accurate cholesterol measurement ~ethoqs be. us,ed to identify those individuals at risk. At present, the reliability of serum cholesterol measurements in the United States points to the need for more accurate testing methods. The need for more accurate methods for determining cholesterol especially in associatiol). with the various lipoproteins has led to the development of a new method in which cholesterol levels are determined using circular dichroism spectropolarimetry.